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We have 10 Biochemistry (innate) PhD Projects, Programmes & Scholarships

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Biochemistry (innate) PhD Projects, Programmes & Scholarships

We have 10 Biochemistry (innate) PhD Projects, Programmes & Scholarships

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Linking metabolism and metal resistance in pathogenic bacteria (SULLIVANM_U24AMSSCI)

Primary supervisor - Dr Matthew Sullivan. Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Read more

Self-funded PhD- Understanding the molecular mechanism of a bacterial genome defence system and its synergy with CRISPR-Cas

Prokaryotes have evolved over billions of years alongside their viruses, the bacteriophages, or “phages”. To prevent viral infection, prokaryotes have evolved rudimentary immune mechanisms, the most widespread and well-studied of which are the Restriction-Modification and the CRISPR-Cas enzymes. Read more

Cancer: Understanding the immunosuppressive role of fibroblast and macrophages in Breast cancer

Oncolytic viruses (OVs) preferentially infect and kill cancer cells, and their clinical efficacy has been demonstrated against a number of different cancers. The most clinically advanced OV is a genetically engineered herpes simplex virus (T-VEC) which expresses GMCSF to aid the development of anti-tumour immune responses; T-VEC is approved for the treatment of metastatic melanoma. Read more
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