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Biochemistry (recombinant) PhD Projects, Programs & Scholarships

We have 54 Biochemistry (recombinant) PhD Projects, Programs & Scholarships

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  Modelling cellular stress during recombinant protein production for improving upstream biomanufacturing processes
  Dr D Dikicioglu, Prof G Lye
Application Deadline: 29 November 2019

Funding Type

PhD Type

Applications are invited for one PhD studentship to work in modelling the stress imposed on host organisms by recombinant protein production for improving predictive capabilities of upstream bioprocess models employed in biomanufacturing practices.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  In silico design of high-affinity recombinant antibodies
  Dr P Mulheran, Dr V A Ferro
Application Deadline: 30 November 2019

Funding Type

PhD Type

Currently there is a trend to move from small drug molecule therapy to use of biologics such as monoclonal antibodies (mAb).
  Developing a virus-like particle (VLP) Polio vaccine
  Dr G Mulley
Applications accepted all year round

Funding Type

PhD Type

Rationale. Poliovirus is a non-enveloped RNA virus, spread via the faecal-oral route, that causes the infectious disease Poliomyelitis (Polio).
  Identifying Dengue virus receptor proteins in Aedes aegypti mosquito
  Dr A Winter
Applications accepted all year round

Funding Type

PhD Type

Neglected tropical diseases caused by the Dengue virus (DENV), endemic Dengue fever and its more severe manifestation, Dengue syndrome, cause great socioeconomic loss as well as high mortality in Asia and South America.
  Rational engineering of NMDAR subunit-specific peptide affinity reagents and their pharmacological and functional characterisation as novel subtype specific NMDAR ligands.
  Dr M Soloviev
Applications accepted all year round

Funding Type

PhD Type

The aim of this project is to engineer subunit-specific anti-GluN1/2/A/B polypeptide affinity reagents and to characterise their pharmacological specificity and functional activity on the recombinant NMDARs expressed in heterologous expression systems and on native NMDARs in hippocampal slice preparations.
  (BBSRC DTP) Engineering novel stress-resilient microalgae strains as improved platform strains for industrial biotechnology
  Dr J Pittman, Dr P Gallois, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

Microalgae have potential as photosynthetic cell factories for the production of chemicals and metabolites that can be used for industrial applications or as platform strains for the production of recombinant proteins.
  Investigating the Drosophila DF31 protein to gain insight into the mechanisms and chromatin maintenance in animal cells
  Dr S Cotterill, Dr A Nohturfft
Applications accepted all year round

Funding Type

PhD Type

The Drosophila DF31 protein is an abundant ribonucleoprotein that localises to euchromatic regions and is involved in maintaining chromosome structure.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  (BBSRC DTP) Understanding structure and function of the mechanosensors talin and vinculin
  Dr C Ballestrem, Prof C Baldock, Dr A Roseman
Application Deadline: 31 January 2020

Funding Type

PhD Type

The ability of cells to sense biochemical and mechanical properties of their extracellular matrix (ECM) environment is critical for the development of functional tissue.
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