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Biochemistry (repair) PhD Projects, Programs & Scholarships

We have 23 Biochemistry (repair) PhD Projects, Programs & Scholarships

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  DNA Damage and Repair: Studying DNA damage and repair to understand the causes of cancer and improve its treatment
  Prof P McHugh, Prof J Rehwinkel, Prof A Harris
Application Deadline: 26 July 2019

Funding Type

PhD Type

Our DNA is constantly under threat from damaging agents. If unrepaired this DNA damage can lead to errors during genome duplication, including the mutations that can lead to cancer and other human diseases.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  Harnessing inflammation to repair extracellular-matrix rich tissues
  Dr M Sherratt, Dr G Lopez-Castejon, Dr C Platt
Applications accepted all year round

Funding Type

PhD Type

Inflammation is thought to play a key role in mediating many aspects of both age and disease. The aberrant expression of tissue proteases is a hallmark of inflammation.
  DNA replication, recombination and repair in Archaea
  Dr T Allers, Dr E Bolt
Applications accepted all year round

Funding Type

PhD Type

Additional Supervisor. Anita Marchfelder (University of Ulm, Germany). Archaea are the third domain of life, alongside eukaryotes and bacteria.
  Promoting tissue repair with natural cell-signalling peptides
  Dr M Sherratt, Dr A P Gilmore, Dr M Ozols
Applications accepted all year round

Funding Type

PhD Type

In many tissues damage to the extracellular matrix (ECM) can accumulate over a lifetime resulting in the functional manifestations of skin ageing and diseases such as arteriosclerosis, emphysema and arthritis.
  Discovering new DNA repair enzymes using archaea as a model for mammals
  Dr E Bolt, Dr T Allers
Applications accepted all year round

Funding Type

PhD Type

This PhD research project will combine protein biochemistry and molecular biology methods, and will provide detailed training into how to analyse gene and protein function.
  Activation of targeted DNA Damage Response as a novel therapy for Ovarian Cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer and accounts for 70% of all ovarian cancer deaths.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round

Funding Type

PhD Type

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Chromatin and maintenance of genome stability
  Dr A Chambers
Applications accepted all year round

Funding Type

PhD Type

Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019

Funding Type

PhD Type

It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
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