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We have 12 Biochemistry (toxicity) PhD Projects, Programmes & Scholarships

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Biochemistry (toxicity) PhD Projects, Programmes & Scholarships

We have 12 Biochemistry (toxicity) PhD Projects, Programmes & Scholarships

Linking metabolism and metal resistance in pathogenic bacteria (SULLIVANM_U24AMSSCI)

Primary supervisor - Dr Matthew Sullivan. Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Read more

Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Tailoring Unspecific Peroxygenases (UPOs) for Applications in Synthetic Organic Chemistry

Background. The oxygenation of organic compounds presents an ongoing challenge to synthetic chemistry as conventional reagents present difficulties with toxicity, harsh conditions and poor selectivity. Read more

Enzyme-responsive peptide hydrogels as in situ forming long-acting drug delivery implants

One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more

The development and application of metabolomics tools to study human metabolism in health and disease

Metabolites play many important roles in humans including through metabolism to support our growth and health, through incorporation of lipids in cell membranes to influence transport of biochemicals in to and out of cells and to regulate biochemical processes. Read more

Chaperones and the response to protein misfolding stress

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
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