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Biochemistry (antimicrobial) PhD Projects, Programs & Scholarships

We have 60 Biochemistry (antimicrobial) PhD Projects, Programs & Scholarships

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  Protease-resistant antimicrobial peptides to target bacterial and fungal pathogens
  Dr J Bella, Dr L Tabernero
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is quickly becoming a serious global health problem. The emergence of multidrug-resistant microbial strains combined with the drying up of the antibiotic pipeline in the pharmaceutical industry has significantly worsened the situation in recent years.
  MRC DiMeN Doctoral Training Partnership: Targeting pathogen subversion of cellular ageing to combat antimicrobial-resistant typhoid fever
  Dr D Humphreys, Prof S Baker, Dr T Darton
Application Deadline: 6 January 2020

Funding Type

PhD Type

- Antimicrobial-resistant typhoid fever is fuelled by chronic Salmonella carriage. The world faces epidemics of untreatable typhoid fever caused by antimicrobial-resistant strains of Salmonella Typhi (~27 million cases/year).
  Genome mining of novel antimicrobial natural products from new bacterial strains
  Dr H Deng, Prof M Jaspars
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Mechanism of Bacterial Resistance to Antimicrobial Peptides
  Prof Mibel Aguilar
Application Deadline: 31 March 2020

Funding Type

PhD Type

Antibiotic resistance continues to emerge and intensify.
  (BBSRC DTP) Novel antimicrobial discovery using high-throughput pathway assembly and robotics
  Prof E Takano, Prof A Munro, Prof R Breitling
Application Deadline: 31 January 2020

Funding Type

PhD Type

Recent advances in molecular biology, in particular our improved ability to read and (most importantly) write genomic sequences, have led to renewed excitement in the area of genetic engineering, i.e.
  GW4 BioMed MRC DTP PhD studentship: Defining the role of efflux in bacterial biofilm formation and antimicrobial resistance to develop new treatments for infection
  Dr B V Jones
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  EASTBIO Antimicrobial peptide signalling to CD8+ T cells
  Dr E Gwyer Findlay, Dr M Swamy
Application Deadline: 5 January 2020

Funding Type

PhD Type

CD8+ T cells are essential for robust immune responses to pathogens, particularly in the intestine. We are interested in how antimicrobial peptides – released from neutrophils and mucosal epithelial cells – affect the differentiation of, and cytokine production by, CD8+ T cells.
  MRC DiMeN Doctoral Training Partnership: Killing the unkillable. Developing bacterial capture compounds to identify new targets against antimicrobial resistant Staphylococcus aureus
  Dr R Corrigan, Dr D Williams
Application Deadline: 6 January 2020

Funding Type

PhD Type

The “superbug”, Methicillin resistant Staphylococcus aureus (MRSA) is a major threat to global health. Once inside a host, bacteria, like S.
  MRC DiMeN Doctoral Training Partnership: Killing the unkillable. Developing bacterial capture compounds to identify new targets against antimicrobial resistant Staphylococcus aureus
  Dr R Corrigan, Dr D Williams
Application Deadline: 6 January 2020

Funding Type

PhD Type

The “superbug”, Methicillin resistant Staphylococcus aureus (MRSA) is a major threat to global health. Once inside a host, bacteria, like S.
  MRC DiMeN Doctoral Training Partnership: Sharpening the blunted neutrophil response to antimicrobial resistant fungal infection
  Dr P Elks, Prof A Condliffe, Dr V See, Dr S Johnston
Application Deadline: 6 January 2020

Funding Type

PhD Type

Life-threatening invasive fungal infection is a major health problem in the immunocompromised, and emerging drug resistance is a major threat to global health.
  How does a new antimicrobial kill the fungi that invade immunosuppressed patients?
  Prof T Levine
Application Deadline: 24 January 2020

Funding Type

PhD Type

Hard-to-treat fungal infections are a growing problem both UK and worldwide (rates respectively 10,000 and 2M/year; mortality 40% and 25%).
  Countering antimicrobial resistance: investigating β-lactamase inhibitors using atomistic simulation and experiment
  Dr M van der Kamp, Dr J Spencer, Prof A J Mulholland, Prof T Walsh
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ for entry in September/October 2020.
  The bacterial protein translocation machinery: a target for new strategies against antimicrobial resistance
  Prof I Collinson
Applications accepted all year round

Funding Type

PhD Type

Bacterial resistance to antibiotics is a major problem affecting millions of people across the world. This severely affects treatment of bacterial infections as strains are emerging that are totally resistant to all clinically used antibiotics.
  The maintenance of virulence and antimicrobial resistance in Shigella
  Prof C Tang
Application Deadline: 10 January 2020

Funding Type

PhD Type

Shigella spp are the main cause for dysentery worldwide, and emerged from commensal Escherichia coli following acquisition of a 210 kb virulence plasmid.
  (BBSRC DTP) Metals and bacterial virulence: overcoming metal intoxication during infection
  Dr J Cavet, Dr D Linton, Prof J Lloyd
Application Deadline: 31 January 2020

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen, being the leading bacterial cause of human acute gastroenteritis and responsible for an estimated 0.5 billion cases each year.
  Novel synthetic approaches to antimicrobial natural products and investigations of their bioactivity
  Prof A Malkov
Applications accepted all year round

Funding Type

PhD Type

The aim of the project is to develop new highly effective anti-tubercular agents. Previously, it has been established that terpenes isolated from marine organisms possess a number of important antibacterial properties.
  (BBSRC DTP) From mucin biochemistry to pulmonary immunity: How do mucins promote antimicrobial lung defences?
  Prof E Bignell, Prof D Thornton, Dr A Horsley
Application Deadline: 31 January 2020

Funding Type

PhD Type

Respiratory mucus plays multiple essential roles in mammalian lung function, from hydrating the epithelium and supporting gaseous exchange, to expelling inhaled particles and microbes and providing a conduit for innate and adaptive immune signaling.
  MRC DiMeN Doctoral Training Partnership: Design and Optimisation of Red/NIR Fluorescent Dyes for the Assessment of Antimicrobial Susceptibility
  Prof D Kell, Dr G Nixon
Application Deadline: 6 January 2020

Funding Type

PhD Type

The current anti-microbial resistance (AMR) crisis is well documented and the need for a very rapid antibiotic susceptibility test is key to preventing mis-diagnosis and subsequent mis-prescribing.
  Towards broad spectrum antimicrobial vaccines: uniting automated and enzymatic glycan assembly for the synthesis and bioconjugation of the biofilm exopolysaccharide PNAG
  Dr M A Fascione, Prof G Davies
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. There is a pressing need for antibodies and vaccines of improved efficacy, and improved methods for their production.
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Analysis and Treatment of Orthopaedic Pin Site Infections
  Dr J McEvoy
Applications accepted all year round

Funding Type

PhD Type

Pin site infections are a major complication of external fixation of fractures, and bacterial biofilms are known to form on the pin surface.1 This project, in collaboration with Dr Shobana Dissanayeke (RHUL) and St Peter’s Hospital, Chertsey, will investigate bacterial biofilms that have been obtained from percutaneous pins used in orthopaedic fixation frames.
  Silver ion-based antimicrobials: mechanisms of toxicity and resistance
  Dr G Mulley, Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

"The emergence and persistence of bacterial strains with resistance to multiple classes of antibiotics has led to renewed interest in the antimicrobial properties of silver ions.
  Bacterial iron uptake pathways as targets for the development of novel antimicrobials
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is an ever increasing problem. Presently it is estimated to be responsible for 700,000 deaths p.a. and it is predicted that this figure will rise to 10 million by 2050.
  Evaluation of natural plant based botanicals as alternative to therapeutic antibiotics
  Dr C Situ
Applications accepted all year round

Funding Type

PhD Type

It has become widely recognised that antimicrobial resistance (AMR) is one of the biggest health threats that mankind faces encompassing huge health and economic burdens on governments and societies in every region of the globe.
  (BBSRC DTP) Discovery and Editing Pathways to New Antibiotics
  Prof J Micklefield, Prof D Leys, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

There is an urgent need for new antibiotics. The majority of antibiotics that are used to treat infectious diseases today are small molecules produced by microorganisms, called natural products, or derivatives thereof.
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  Unravelling the mechanism of glutamyl-tRNA reductase, a target for broad-spectrum antibiotic development
  Research Group: Biomedical Sciences Research Centre
  Dr RG Da Silva
Application Deadline: 1 December 2019

Funding Type

PhD Type

Antimicrobial resistance is on the rise. This global threat is predicted to claim more lives than cancer by 2050 if not properly addressed.
  Imperial MRC DTP PhD Studentships 2020-21

Funding Type

PhD Type

Imperial College London is offering up to 10 fully funded PhD studentships to start in 2020-21. As part of this support, funding is provided at the end of three years for a six month writing up period.
  Discovery of Antibiotics from Cyanobacteria (TRUMANJ20DTP)
  Dr A Truman
Application Deadline: 25 November 2019

Funding Type

PhD Type

Bacteria have the capacity to produce natural products with exquisite bioactivities, which makes these compounds excellent candidates as medicines and agrochemicals.
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