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Biochemistry (death) PhD Projects, Programs & Scholarships

We have 54 Biochemistry (death) PhD Projects, Programs & Scholarships

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  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Budding yeast as a model for sudden cardiac death
  Dr T Hoefken
Applications accepted all year round

Funding Type

PhD Type

Sudden unexpected cardiac death is responsible for about half of all heart disease deaths. It is an unexpected death caused by a change in heart rhythm.
  (BBSRC DTP) Understanding the role of RNA binding proteins in the regulation of NF-kappa B dynamics, inflammation and cell death
  Prof M White, Dr A P Gilmore, Prof S Griffiths-Jones, Dr M Muldoon
Application Deadline: 31 January 2020

Funding Type

PhD Type

NF-kB is a key signalling system that controls inflammation and cell fate, dysregulation of which can lead to inflammatory disease or cancer.
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round

Funding Type

PhD Type

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Evolution Education Trust PhD project - The evolution of eukaryotic gene order: Following the birth, life and death of a eukaryotic gene cluster
  Dr H-W Nützmann, Dr D A Henk
Application Deadline: 5 February 2020

Funding Type

PhD Type

The University of Bath is inviting applications for this PhD opportunity based at the Milner Centre for Evolution, a unique, cross-faculty research centre bridging biology, health and education.
  Determining novel molecular regulators of necrosis controlling premature cell death
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases.
  The role of protein turnover in bacterial life and death
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

The control of protein levels in bacterial cells is essential for their growth and survival. This is an interplay between protein synthesis and turnover.
  PhD Studentship Opportunity in Sudden cardiac death in human athletes – electrophysiological and molecular insights from the animal models
  Dr K Jeevaratnam
Applications accepted all year round

Funding Type

PhD Type

This is an exciting fully funded PhD studentship opportunity exploring the electrophysiological and molecular profile of the equine heart as a model for high performing human athletes.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  RVC PhD: Rebalancing mitochondrial metabolism in Duchenne Muscular Dystrophy - a novel therapeutic avenue?
  Dr C Thornton, Prof D Wells
Application Deadline: 9 February 2020

Funding Type

PhD Type

Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disease caused by mutations in the DMD gene that lead to the loss of a functional version of the subsarcolemmal protein dystrophin.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  Proteolytic network regulating the human innate immune response
  Dr D Boucher, Prof I Hitchcock
Application Deadline: 30 June 2020

Funding Type

PhD Type

The innate immune system is our first line of defence against a wide range of bacteria and viruses. Upon infection, immune cells, such as macrophages and neutrophils, will assemble signalling platforms termed inflammasome, to restrict and clear the insult.
  Impact of the immune landscape on androgen ablation therapy and progression to therapy-resistant disease
  Prof I McEwan, Prof H M Wilson, Dr S R Dundas
Application Deadline: 17 February 2020

Funding Type

PhD Type

Prostate cancer is the most commonly diagnosed cancer in men and is a leading cause of cancer related death. The androgen receptor is important for the development and function of the prostate gland and is a driver of prostate cancer progression and metastasis.
  Validating and Exploiting Inositol Phosphoryl Ceramide Synthase as a Novel Herbicide Target
  Prof P Steel
Application Deadline: 31 July 2020

Funding Type

PhD Type

With the global population predicted to continue rising there is a need for more efficient food production. An essential component of sustainable intensive cereal production is effective crop protection agents.
  Deciphering p53 signaling
  Dr M Muller, Dr A Politis
Application Deadline: 24 January 2020

Funding Type

PhD Type

We are offering a fully-funded studentship for an outstanding PhD candidate who will produce and study PTM variants of p53 to deepen our understanding of the function and regulation of this key tumour suppressor protein.
  Deciphering p53 signaling
  Dr M Muller, Dr A Politis
Application Deadline: 24 January 2020

Funding Type

PhD Type

We are offering a fully-funded studentship for an outstanding PhD candidate who will produce and study PTM variants of p53 to deepen our understanding of the function and regulation of this key tumour suppressor protein.
  Four Year Integrated PhDs in Cancer, Immunology, Infection and Biomedicine

Funding Type

PhD Type

The Faculty of Medicine at the University of Southampton has a strong reputation in research, enterprise and education, with an emphasis on translating new discoveries from basic science into clinical innovation.
  Mitochondrial calcium in neurodegeneration (PhD in Biological Science at the MRC Mitochondrial Biology Unit)
  Dr A J Whitworth
Application Deadline: 30 June 2020

Funding Type

PhD Type

Mitochondrial calcium plays a key role in a wide array of cellular homeostatic processes as diverse as bioenergetics and cell death, and has been linked to disease conditions as varied as cancer, ischemia-reperfusion injury and neurodegeneration (1-3).
  Breast Cancer Omics and Modelling
  Dr C Francavilla, Prof R Breitling
Applications accepted all year round

Funding Type

PhD Type

Background and goals. Breast cancer is the major cause of death among women and 90% of deaths are caused by incurable metastasis.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Membrane protein misfolding and disease: quality control pathways
  Dr L Swanton, Prof P Woodman
Applications accepted all year round

Funding Type

PhD Type

Misfolded proteins represent a continuous threat to cell viability, and if allowed to accumulate, can disrupt cellular function and induce cell death.
  A novel therapeutic targeting the inflammasome as a treatment for glaucoma.
  Dr V McGilligan, Dr S Atkinson, Prof C Willoughby
Application Deadline: 7 February 2020

Funding Type

PhD Type

Glaucoma is the leading cause of irreversible blindness and is a global problem that affects over 60 million people. Unfortunately, there is no cure for this disease and, with the rapidly expanding aging population, the number of people diagnosed with glaucoma is predicted to exceed 100 million by 2040.
  Soma-Germline communication and the role of cortical polarity in signalling regulation during Drosophila spermatogenesis
  Dr F Papagiannouli
Application Deadline: 31 March 2020

Funding Type

PhD Type

Stem cells have the unique capacity to develop into specialized cell types in our tissue and organ systems. They are critical for multi-cellular development, since they supply the new cells that build up our bodies as we grow and replenish, as we age, worn out, damaged, and diseased tissues.
  Developing new antimicrobials
  Dr T Narancic
Application Deadline: 31 January 2020

Funding Type

PhD Type

Antibiotic resistance is documented by the World Health Organisation as one of the three most important threats to human health.
  Regulation of host cell DNA damage response pathways by adenovirus
  Dr A S Turnell, Dr C McCabe
Applications accepted all year round

Funding Type

PhD Type

Human adenoviruses are small non-enveloped viruses with a linear, double-stranded DNA genome. Adenovirus has long served as a faithful model for dissecting the molecular basis of key cellular signalling pathways that regulate fundamental biological processes such as cell growth, cell differentiation and cell death.
  Identification of colistin resistant gene, mcr-1, in clinical isolated Enterobacteriaceae and characterisation of pathogenicity and virulence of mcr-1 harboured bacterial pathogens
  Research Group: Chemistry and Biosciences
  Dr C Chang, Dr J N Fletcher
Applications accepted all year round

Funding Type

PhD Type

Globally, infectious disease accounts for more than 13 million deaths a year and is one of the main causes of death around the world, predominantly in developing countries.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
  Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Prof C Wright
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  Improving access to diabetes testing in the community. (EnglishEU19SF)
  Dr E English, Prof J Wain
Application Deadline: 31 May 2020

Funding Type

PhD Type

Diabetes is a major global health burden and is the 7th leading cause of death worldwide. Early identification and treatment of the disease has been shown to reduce the rate of complications.
  Therapeutic approaches and family engagement for a neurodevelopmental disorder: what does a diagnosis of EEF1A2 really mean?
  Prof C Abbott, Dr S Fletcher-Watson
Application Deadline: 26 January 2020

Funding Type

PhD Type

The newly established four-year Medical Sciences & Translational Research PhD with integrated studies in Engagement for Impact Programme will combine medical…
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