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Biochemistry (equality) PhD Projects, Programmes & Scholarships

We have 68 Biochemistry (equality) PhD Projects, Programmes & Scholarships

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Fluorinated tools for chemical biology

University of Edinburgh School of Chemistry
A PhD studentship is available in the group of Dr Chris Coxon, School of Chemistry, University of Edinburgh, https://www.chem.ed.ac.uk/staff/academic-staff/dr-christopher-r-coxon. Read more
 Supervisor: Dr C Coxon
 31 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Development of an ambient mass spectrometry platform for rapid mass spectrometry characterisation of proteins

University of Edinburgh School of Chemistry
A PhD studentship is available in the group of Dr. Read more
 Supervisor: Dr D Clarke
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

The University of Manchester Faculty of Biology, Medicine and Health
Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more
 Supervisors: Prof D Brough, Dr K Couper
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health
Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more
 Supervisors: Dr A Politis, Dr CP Pliotas
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Bringing Palladium Chemistry into the Biocatalytic Toolbox.

University of Edinburgh School of Chemistry
A PhD studentship is available in the group of Dr Amanda Jarvis, School of Chemistry, University of Edinburgh, (https://www.amandajarvis.co.uk/ ). Read more
 Supervisor: Dr A Jarvis
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes

The University of Manchester Faculty of Biology, Medicine and Health
A self-funded PhD studentship is available in the laboratories of Andrew McBain, Stefan Meyer and Chris Knight. The project aims to study the microbiome in paediatric cancer predisposition and chromosomal instability syndromes (CIS). Read more
 Supervisors: Prof A McBain, Dr S Meyer, Dr C Knight
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

The University of Manchester Department of Chemistry
Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more
 Supervisor: Dr C Megarity
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more
 Supervisors: Prof R O'Keefe, Prof B Newman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry
Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more
 Supervisor: Prof S Hay
 27 October 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Unlocking the potential of plant cellulose for the production of new materials and chemicals

The University of Manchester Faculty of Biology, Medicine and Health
Plant biomass, in the form of plant cell walls are the only renewable resource sufficiently abundant to make a meaningful contribution to decreasing CO. Read more
 Supervisors: Prof S Turner, Dr J Pittman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health
Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more
 Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health
Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more
 Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health
Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more
 Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health
The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more
 Supervisors: Prof CN O'neill, Prof A McBain
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
 Supervisors: Prof C M Grant, Prof M Ashe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health
Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more
 Supervisors: Prof G D Pavitt, Dr A Roseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Graphene oxide as growth factor carriers for meniscus tissue engineering

The University of Manchester Faculty of Biology, Medicine and Health
Damage to the meniscus of the knee leads to increased risk of osteoarthritis. Tissue engineering of a healthy meniscal fibrocartilage offers the opportunity to restore function. Read more
 Supervisors: Dr H Lu, Dr S Richardson, Prof P Xiao
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni

The University of Manchester Faculty of Biology, Medicine and Health
Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. Read more
 Supervisors: Dr J Cavet, Dr D Linton
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identification of transcriptomic signatures of autism-like neurodevelopmental disorder

The University of Manchester Faculty of Biology, Medicine and Health
The overarching aim of this project is to define transcriptional patterns and identify new genetic elements essential for the correct development of the human brain. Read more
 Supervisors: Dr PG Grzechnik, Dr A J Whitmarsh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Circadian mechanisms in psoriasis: therapeutic opportunities

The University of Manchester Faculty of Biology, Medicine and Health
Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more
 Supervisors: Dr H Young, Dr I Iqbal, Prof D Ray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating monogenic disorders of the protein synthesis machinery

The University of Manchester Faculty of Biology, Medicine and Health
Translation of mRNA into proteins is a critical cellular biological process. We recently described a novel human disorder, now called Faundes-Banka Syndrome (FABAS), caused by heterozygous variants in EIF5A1 that encodes a translation factor. Read more
 Supervisors: Dr P Kasher, Dr S Banka, Prof G D Pavitt
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health
RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more
 Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Tailoring Unspecific Peroxygenases (UPOs) for Applications in Synthetic Organic Chemistry

University of York Department of Chemistry
Background. The oxygenation of organic compounds presents an ongoing challenge to synthetic chemistry as conventional reagents present difficulties with toxicity, harsh conditions and poor selectivity. Read more
 Supervisors: Prof G J Grogan, Dr W Unsworth, Dr J Cartwright
 20 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Mechanisms underlying the effects of activated protein C (APC) in cardiac muscle

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
APC is an anticoagulant enzyme that also exerts antithrombotic, anti-inflammatory, antiapoptotic and a variety of other cytoprotective effects in different tissues, where the mechanism of action is thought to involve the endothelial protein C receptor (EPCR) and a protease activated receptor (PAR). Read more
 Supervisors: Dr M Hussain, Dr T Nasim, Prof MR Boyett
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

The University of Manchester Department of Chemistry
Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more
 Supervisors: Dr S Lovelock, Dr C Markin
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Sustainable bio-hydrogen production via engineered microbial metabolism (4-year fully funded PhD studentship with Dstl)

University of Edinburgh School of Biological Sciences
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Background and the project. In 2022, carbon emissions from the chemical industry peaked at 935 M ton, making this industry the third largest sector by emissions and responsible for 2.5% of total greenhouse gas emissions worldwide. Read more
 Supervisor: Prof S Wallace
 22 April 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Characterisation of adrenoceptor and muscarinic receptor subtypes coupled to potassium channels in chondrocytes from bovine cartilage

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Several outward potassium currents have been identified in bovine chondrocytes (review Mobasheri et al. 2012). These include ATP-sensitive and a Calcium-activated potassium currents (Sanches & Lopez-Zapata, 2011). Read more
 Supervisors: Dr M Hussain, Dr M Katsikogianni, Dr N Javid
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Beat-to-beat modulation of Calcium-induced Calcium release in cardiac muscle

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Contraction in the heart is well known to be dependent on a transient rise in intracellular calcium concentration. Read more
 Supervisors: Dr M Hussain, Dr J Muller, Prof MR Boyett
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of the extracellular matrix as a regulator of Parkinson’s progression

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Parkinson’s is the 2nd most common neurodegenerative disease, affecting around 1 in 20 people aged over 65. In the UK, the number of affected people is set to rise by 50% over the next 50 years due to ageing populations. Read more
 Supervisor: Dr SM Dickens
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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