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Biochemistry (genes) PhD Projects, Programs & Scholarships

We have 63 Biochemistry (genes) PhD Projects, Programs & Scholarships

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  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  Engineering tRNA neochromosomes in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Using canine models of obesity to discover the mechanisms by which genes influence obesity.
  Dr E Raffan, Dr D Sargan
Applications accepted all year round

Funding Type

PhD Type

We are interested in discovering the mechanisms by which genes influence obesity. The dog is an excellent model organism for human comparative analyses.
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  Control of tissue growth and cancer by the Hippo pathway
  Dr K. Harvey, Dr C Poon
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Targeting addiction to a breast cancer metastasis survival pathway by inhibition of RAN GTPase
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Prof M El-Tanani, Dr S Betmouni
Applications accepted all year round

Funding Type

PhD Type

Metastatic cancer is a major global health burden. Each year, eleven million new cases of cancer are diagnosed worldwide, including 5 million cases in industrialized countries.
  How non-Mendelian inheritance sculpts genome evolution
  Dr P Ellis, Dr M Farré Belmonte
Application Deadline: 6 September 2019

Funding Type

PhD Type

This is a FULLY FUNDED project sponsored by the Leverhulme Trust. The scholarship covers Home/EU fees and full RC stipend (£15,009 2019/20) rate for four years.
  Seeking critical branch points in bacterial evolution with comparative genomics
  Prof N Saunders, Mr A Khan
Applications accepted all year round

Funding Type

PhD Type

This is a bioinformatics and comparative genomics-focussed project, seeking to identify the basis of speciation and sub-speciation of bacterial species accounting for the development of individual and independent lineages.
  Defining diets to treat inborn errors of metabolism
  Dr T Johnson, Dr M Piper
Applications accepted all year round

Funding Type

PhD Type

Fully funded PhD scholarships are available for both Australian and international students through the School of Biological Sciences and Monash University.
  Transcriptional responses to cellular stress
  Dr PG Grzechnik
Applications accepted all year round

Funding Type

PhD Type

Position for a PhD student is available in the group of Dr Pawel Grzechnik at the University of Birmingham. The aim of the project is to understand how eukaryotic cells remodel RNA biology in order to survive stress generated by pathological conditions and external stressors.
  Gene Regulation by the KAT6A/MOZ Histone Acetyltransferase
  Prof D Heery
Applications accepted all year round

Funding Type

PhD Type

The human KAT6A and KAT6B genes encode the nuclear proteins MOZ and MORF, which are key gene regulators in development of blood, brain and other tissues.
  Molecular dissection of activity-dependent neuronal signalling pathways using quantitative proteomics
  Dr M Collins
Applications accepted all year round

Funding Type

PhD Type

Recent proteomic investigations have identified several thousand proteins in biochemically purified synapses and have uncovered multiprotein complexes essential for synapse function.
  Genome mining of novel antimicrobial natural products from new bacterial strains
  Dr H Deng, Prof M Jaspars
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Transcription control and immune evasion in African trypanosomes
  Research Group: Division of Cell & Molecular Biology
  Prof G Rudenko
Applications accepted all year round

Funding Type

PhD Type

Trypanosomes are unicellular eukaryotes which cause African Sleeping Sickness, which is endemic to subSaharan Africa. Trypanosomes can be easily grown as suspension cell lines in the laboratory, where they are straightforward to manipulate and genetically modify.
  The Role of LIM Domain Only Proteins in Neuroblastoma
  Dr M Hoogenkamp
Applications accepted all year round

Funding Type

PhD Type

Person Specification. An Upper Second Class Honours Degree (or equivalent) in a relevant study or Master’s degree is expected. Prior experience in cell and molecular biology is an advantage.
  Evolution and biochemistry of photosynthesis - electron transfer reactions, renewable energy production, biotechnology, and chloroplast genomes
  Prof C J Howe
Applications accepted all year round

Funding Type

PhD Type

The common theme of our work is the biochemistry and evolution of photosynthesis.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  Adaptation to oxidative stress in hepatitis C virus persistence: the role of IRES-dependent translation.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Hepatitis C virus (HCV) causes a clinically important disease affecting 3% of the world population (Chan 2014). About 75% of the infection will develop into chronic hepatitis, which can then progress into fibrosis, cirrhosis and hepatocellular carcinoma.
  Evolution of vertebrate blood vessels
  Dr T Takahashi, Dr S Herbert
Applications accepted all year round

Funding Type

PhD Type

The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks.
  Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes.
  Silver ion-based antimicrobials: mechanisms of toxicity and resistance
  Dr G Mulley, Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

"The emergence and persistence of bacterial strains with resistance to multiple classes of antibiotics has led to renewed interest in the antimicrobial properties of silver ions.
  How does clubroot obtain nutrients from its living plant host?
  Dr S A Rolfe
Applications accepted all year round

Funding Type

PhD Type

Clubroot is an important pathogen of Brassica crops. The disease is found throughout the world and causes severe economic losses.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development
  Dr V Hernandez
Applications accepted all year round

Funding Type

PhD Type

Bardet-Biedl syndrome (BBS) is a debilitating, often life-limiting heritable multisystem disorder caused by dysfunction of non-motile cilia (ciliopathy).
  Egr2 and 3 mediated T cell tolerance in cancer and their impact in immune checkpoint therapy
  Dr S Li
Applications accepted all year round

Funding Type

PhD Type

Tumour infiltrated lymphocytes (TILs) contain tumour reactive T cells and have been used as adoptive cell transfer therapy in patients which can mediate cancer regression.
  Curing Genetic Muscle diseases
  Dr J Ochala
Applications accepted all year round

Funding Type

PhD Type

Congenital myopathies are a group of genetic muscle diseases with unclear mechanisms and no efficient treatment.
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