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Biochemistry (information studies) PhD Projects, Programs & Scholarships

We have 150 Biochemistry (information studies) PhD Projects, Programs & Scholarships

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  Experimental and Theoretical Studies of the Origin of Life on the Earth
  Prof J Šponer, Ms J Sponerova
Application Deadline: 20 February 2020

Funding Type

PhD Type

Formation of the very first oligonucleotide sequences is one of the greatest mysteries surrounding life’s origin on our planet.
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Bioinformatics studies of protein structures, functions and their interactions
  Dr L J McGuffin
Applications accepted all year round

Funding Type

PhD Type

The computational study of protein structures, functions and their interactions is fundamental to our understanding of disease.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Watching the Hippo pathway in real time in growing organs
  Dr K. Harvey
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Multiscale Modeling of Nucleic Acids
  Prof J Šponer, Prof M Otyepka, Dr MK Krepl
Application Deadline: 1 February 2020

Funding Type

PhD Type

Nucleic acids (RNA and DNA) belong to the most important biomacromolecules. Studies of structure and dynamics of nucleic acids represent an important task of modern life sciences.
  Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics
  Dr L Wong, Dr C F Blanford
Applications accepted all year round

Funding Type

PhD Type

Plastics are a broad range of solid polymeric materials that have found widespread application as industrial components and consumer goods.
  Structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography
  Prof A Mitra
Applications accepted all year round

Funding Type

PhD Type

We are seeking a highly motivated candidate to carry out structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Structural and time-resolved studies of phage replication in bacterial biofilm
  Dr P Plevka
Application Deadline: 20 February 2020

Funding Type

PhD Type

When Staphylococcus aureus cells form a biofilm in the human body they become shielded from the immune system and highly resistant to antibiotics.
  Structural studies of the TPLATE complex
  Dr K Tripsianes
Application Deadline: 20 February 2020

Funding Type

PhD Type

The TPLATE complex (TPC) is essential for endocytosis in plants, yet it is evolutionary lost from yeasts and animals, pointing to the fact that endocytosis is mechanistically regulated differently.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  Testing the function of immune suppressive cytokines and cells in bone metastasis
  Assoc Prof B Parker
Applications accepted all year round

Funding Type

PhD Type

Bone metastasis is a common occurrence in breast and prostate cancer that leads to patient morbidity and, in many cases, mortality.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  Understanding the mechanism of RNA recognition by La-related proteins
  Prof MR Conte
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Prof. Sasi (Maria R) Conte (https://www.kcl.ac.uk/people/sasi-conte), in the Randall Centre for Cell and Molecular Biophysics, King’s College London (https://www.kcl.ac.uk/lsm/research/divisions/randall).
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Micro-environmental Interactions And Non-Coding RNAs In The Biology Of B Cell Leukemia
  Prof M Mráz
Application Deadline: 20 February 2020

Funding Type

PhD Type

We are looking for motivated PhD students for a project funded by the prestigious ERC (European Research Council) Grant (laboratory of Assoc.
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  Small nerve fibre damage and sexual dysfunction in diabetes and obesity. A mechanistic assessment and effect of lipid modifying agents.
  Dr H Soran, Prof R Malik, Dr R Donn, Dr M Ferdousi
Applications accepted all year round

Funding Type

PhD Type

Diabetes and its complications represent a growing global health burden, affecting an estimated 366 million people worldwide.
  Comparative studies of wound and cancer inflammation in plants and animals
  Prof P B Martin
Applications accepted all year round

Funding Type

PhD Type

All organisms need to be able to repair wounds. A key aspect of this is combating the potential for infection when barrier layers are breached by tissue damage.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 April 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Prof C Lygate, Dr S Zervou
Application Deadline: 24 July 2020

Funding Type

PhD Type

Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Investigating metalloprotein mechanism using ‘physiological’ X-ray absorption spectroscopy
  Dr P Ash
Application Deadline: 4 February 2020

Funding Type

PhD Type

A wide variety of metalloproteins, utilising a range of earth-abundant metals, are vital to many biological processes. Changes in metal-based oxidation state are critical to the function of metalloproteins with diverse roles in electron transfer and redox catalysis.
  Fully funded PhD studentship in Computational Chemistry
  Dr D Palmer
Applications accepted all year round

Funding Type

PhD Type

A fully funded, three year PhD Studentship is available in the Department of Pure and Applied Chemistry at the University of Strathclyde under the supervision of Dr David Palmer (Strathclyde).
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