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Biochemistry (metabolism) PhD Projects, Programs & Scholarships

We have 50 Biochemistry (metabolism) PhD Projects, Programs & Scholarships

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  Plant responses to stress, metabolites for health and fuel from cell walls.
  Prof A Devoto
Applications accepted all year round

Funding Type

PhD Type

Projects are available in the following areas. Stress responses in crops and sustainable biomass production and processing. The project aims at elucidating several aspects of the control of plant defences and to identify environmentally friendly forms of plant protectants, leading to enhanced crop yields.
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Maternal anti-hypertensive medicines & placental vascular function
  Dr P Brownbill, Dr J Myers, Dr E Johnstone
Applications accepted all year round

Funding Type

PhD Type

A range of anti-hypertensive medicines are prescribed to women with chronic hypertension in pregnancy, that enter the fetal circulation.
  The mechanism of regulation of protein synthesis via eIF2 molecular complexes
  Dr A Roseman, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2].
  The role mRNA-specific translation during chronological aging
  Prof C M Grant, Prof M Ashe, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Biological ageing can be thought of as a progressive decline in the ability of an organism to survive stress and disease. It is a complex process which is influenced by both genetic and environmental factors.
  Integrating metabolomics, imaging and bioinformatics to develop physiology-based kinetic models for chemical safety science
  Prof M Viant, Dr B Campos, Dr C Rivetti, Dr I Sorrell
Application Deadline: 22 September 2019

Funding Type

PhD Type

**If you are interested in this studentship, it is vital to contact Professor Mark Viant prior to application with a copy of your CV.
  Identifying glucose-dependent mechanisms underlying risk factors for Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr S McLean
Applications accepted all year round

Funding Type

PhD Type

Several risk factors for Alzheimer’s disease including diabetes and midlife obesity are age-dependent and have an obvious metabolic component resulting in impaired glucose metabolism.
  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Bioengineering of bacterial CO2-concentrating system for improved photosynthesis
  Prof LN Liu, Dr D Canniffe
Applications accepted all year round

Funding Type

PhD Type

The single-cell photosynthetic bacteria, cyanobacteria, account for over 25% of global carbon fixation, thanks for their powerful CO2-concentrating machinery.
  Characterising and repurposing cyanobacterial CO2-fixing organelles for metabolic engineering
  Prof LN Liu, Dr J Hartwell
Applications accepted all year round

Funding Type

PhD Type

Compartmentalisation represents an effective strategy used by cells to enhance their activities. By creating physical barriers and compartments, cells sequester the metabolic pathways from the cellular milieu to allow controls of metabolic flux and toxic diffusion.
  Enzymes of endocannabinoid turnover in inflammatory responses
  Dr SPH Alexander
Applications accepted all year round

Funding Type

PhD Type

Over recent years, we have generated, developed and established a wide range of assays for different enzyme activities.
  Sex hormone actions in frailty and health during ageing
  Dr M Garratt
Applications accepted all year round

Funding Type

PhD Type

It is well established that testosterone and estrogens can influence ageing, with hormone administration improving physical function, muscle and bone strength in some cohorts of the elderly.
  The impact of protein ubiquitination on ageing and ageing-associated diseases
  Dr E Kevei
Applications accepted all year round

Funding Type

PhD Type

"Ageing is characterized by a general functional decline of cells, tissues and organs with increased risk of disease, such as neurodegenerative disorders.
  The relationship between dietary iron and zinc, and the gut microbiota: Can dietary iron and zinc regime be exploited to improve health?
  Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

"The gut microbiota (100 trillion cells) outnumber human cells by 10 to 1. Its composition of around 500 to 1000 species is specific for each individual and is dynamic, changing with age, health and diet.
  Exploring the role of OGG1 in fibroblast senescence
  Dr D Lambert, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Fibroblasts are the major cell type of connective tissue. They play a critical role in maintaining the extracellular matrix, the ‘glue’ in which most cells reside, and maintaining normal function of other types of cells such as epithelial and immune cells.
  PhD in the Biosynthesis and Enzymology of Fluorine Containing Metabolites in Streptomyces Bacteria
  Prof D O'Hagan
Applications accepted all year round

Funding Type

PhD Type

Research in the O’Hagan group has had a focus on the biosynthesis of fluorine containing natural products and the identification of a fluorination enzyme, ‘the fluorinase’, from Streptomyces cattleya.[1] Fluorine is very rare in nature, and in those rare cases where an organism can form a C-F bond from fluoride ion, then the enzymology is unique and interesting.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  High-throughput mechanobiology
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

Cancer research has traditionally focused upon extra- or intra-cellular biochemical signals, and their relation to cancer development and metastasis.
  Treating cancer by targeting the mechanical properties of cells
  Dr A Gad
Applications accepted all year round

Funding Type

PhD Type

Cancer development is marked by massive increase of matrix fibres around tumor cells, which changes the mechanical properties of the tissue and is used to diagnose tumours by manual palpation.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round

Funding Type

PhD Type

We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
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