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Biochemistry (pharmacology) PhD Projects, Programs & Scholarships

We have 40 Biochemistry (pharmacology) PhD Projects, Programs & Scholarships

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  AstraZeneca/Pharmacology 4 year PhD studentship

Funding Type

PhD Type

Applications are invited for 4-year PhD studentship funded by AstraZeneca and the Department of Pharmacology. The student will be working on collaborative projects co-led by departmental supervisors and AstraZeneca scientists.
  AstraZeneca/Pharmacology 4 year PhD studentship

Funding Type

PhD Type

Applications are invited for 4-year PhD studentship funded by AstraZeneca and the Department of Pharmacology. The student will be working on collaborative projects co-led by departmental supervisors and AstraZeneca scientists.
  Molecular Pharmacology of N-Methyl-D-aspartate glutamate receptors
  Dr P Chen
Applications accepted all year round

Funding Type

PhD Type

Fast neuronal communication at synaptic contacts relies on neurotransmitter release from the presynaptic terminal and the majority of excitatory neurotransmission within the mammalian central nervous system is mediated by the neurotransmitter glutamate.
  Improving the success of antibody based drugs by characterising the patients’ immune system
  Dr A Watts
Application Deadline: 17 November 2019

Funding Type

PhD Type

The University of Bath, in conjunction with Qualasept Ltd, is inviting applications for a fully-funded PhD studentship. SUPERVISORY TEAM.
  SWBio DTP PhD project: Role of microRNAs in regulating sex differences in stress responsive neurocircuitry across the lifespan
  Prof M Lindsay, Dr S J Bailey
Application Deadline: 2 December 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP).
  Neuropeptide Research - PhD Opportunity at a World Class Institution
  Assoc Prof M Muttenthaler, Assoc Prof I Vetter
Applications accepted all year round

Funding Type

PhD Type

We are seeking talented and highly motivated PhD candidates for the following multidisciplinary project. Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Quantitative Allele-Specific Proteomics in Drug Metabolism and Disposition
  Dr J Barber, Dr B Achour, Prof A Rostami
Applications accepted all year round

Funding Type

PhD Type

The effective dose of a drug is subject to considerable inter-individual variation because the enzymes that metabolise drugs and the proteins that transport them in and out of cells exist, in many cases, in different polymorphic forms and are expressed in varying concentration.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  Targeting the Gas6-TAM receptor signalling pathway in cancer
  Dr S Hafizi
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a self-funded 3 year full-time PhD project, to commence in October 2019 or February 2020. The PhD will be based in the School of Pharmacy and Biomedical Sciences and will be supervised by Dr Sassan Hafizi.
  GW4 BioMed MRC DTP PhD studentship: Structure of ART Toxins: understanding toxicity through host receptor interactions
  Prof R Mrsny, Dr G Masuyer
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  EASTBIO: Development of inducible protein targeting to regulate G-protein-coupled receptor function.
  Dr J Hislop, Dr G Sapkota
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Dr James Hislop (University of Aberdeen). https://www.abdn.ac.uk/people/james.hislop. Dr Gopal Sapkota (University of Dundee).
  StAR International PhD Programme

Funding Type

PhD Type

The Strategic Academic Recruitment (StAR) International PhD programme aims to attract high-achieving international students to an efficient four-year structured PhD training programme at RCSI.
  Assessing the Behaviour of Endotoxin in Biopharmaceutical Formulations: towards creating improved medicines
  Dr A Golovanov
Application Deadline: 15 November 2019

Funding Type

PhD Type

Supervisors. Dr Alexander Golovanov (The University of Manchester) and Dr Adrian Podmore (AstraZeneca). Biopharmaceuticals are the fastest-growing type of treatments for wide range of diseases, with enormous potential for personalised medicine.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Investigating the role of bioactive lipids in skin health
  Prof A Nicolaou, Prof C A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions.
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Developing a tissue engineered/polyurethane blood vessel using bioengineering techniques
  Research Group: Chemistry and Biosciences
  Prof S Rimmer, Prof A M Graham, Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Vein graft failure is a significant issue in cardiovascular disease patients, with restenosis caused by alterations in flow patterns leading to remodelling and disease progression.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
  Polysialyltransferases as a target in metastatic cancer
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases.
  Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Prof C Wright
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  How does the vascular matrix environment influence platelet activation?
  Dr S Calaminus
Application Deadline: 31 March 2020

Funding Type

PhD Type

The platelet is a blood cell that plays a key role in the prevention of bleeding. For platelets to form a clot or thrombus effectively, they must rearrange their actin cytoskeleton to withstand high shear stress from blood flow in the arteries.
  Identification of novel glucose-dependent alterations responsible for platelet dysfunction in Type 2 diabetes.
  Prof Tim Palmer, Dr F Rivero
Application Deadline: 31 March 2020

Funding Type

PhD Type

Type 2 diabetes mellitus (T2DM) is a growing global healthcare problem. Clinical findings suggest that more than 70% of patients with T2DM will die of cardiovascular diseases (CVDs) including heart attack and stroke.
  Identification of novel glucose-dependent alterations responsible for vascular dysfunction in Type 2 diabetes.
  Prof Tim Palmer, Dr R Sturmey
Application Deadline: 31 March 2020

Funding Type

PhD Type

Diabetes is a growing global healthcare problem. The majority of people living with diabetes have Type 2 diabetes mellitus (T2DM), characterised by a resistance of the body to the action of insulin.
  Modulation of platelet-mediated innate immune responses in chronic lymphocytic leukaemia
  Dr M Arman
Application Deadline: 31 March 2020

Funding Type

PhD Type

Chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia in the Western World. B-cell receptor-induced intracellular signals are critical for the survival of leukaemia cells and disruption of this pathway by the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib is a highly effective CLL therapy.
  Platelets and hypoxia: how do varying oxygen concentrations affect platelet function and signalling?
  Dr M Arman
Applications accepted all year round

Funding Type

PhD Type

Platelets have key functions in regulating haemostasis and maintaining vascular integrity, which can cause cardiovascular disease if unbalanced.
  Precision-cut lung slices to investigate the effect of human rhinovirus on cough and airway inflammation
  Dr L Sadofsky
Application Deadline: 31 March 2020

Funding Type

PhD Type

The human Rhinovirus (RV) is the major cause of the common cold. There are no current treatments or vaccines for the virus other than over the counter preparations to alleviate symptoms.
  Re-purposing diabetes medicines to manage bleeding complications in myeloproliferative neoplasms.
  Prof Tim Palmer, Dr D Allsup
Application Deadline: 31 March 2020

Funding Type

PhD Type

Myeloproliferative neoplasms (MPNs) are a group of three related blood cancers in which the bone marrow overproduces one of the three cellular components of blood (erythrocytes, leukocytes and platelets).
  The Role of CCR5 in Embryo Development
  Dr R Sturmey
Applications accepted all year round

Funding Type

PhD Type

Chemokines are small peptides that play key roles in cell migration and signalling. They act primarily by binding specific cell surface receptors to drive intracellular signalling and are key mediators of the immune response.
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