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Biochemistry (cell therapy) PhD Projects, Programmes & Scholarships
We have 25 Biochemistry (cell therapy) PhD Projects, Programmes & Scholarships
We have 25 Biochemistry (cell therapy) PhD Projects, Programmes & Scholarships
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Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting.
Research Group:
Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more
Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy
Research Group:
Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more
Imaging redox regulation in metastatic cancers
Cancer can spread throughout the body (metastasis) by which time it is no longer curable through surgery alone. Metastasis is the leading cause of death in cancer patients, and are frequently therapy-resistant. Read more
Self funded BMS Project: Therapeutic potential of extracellular vesicles from different mesenchymal stem cell subtypes.
Human mesenchymal stem/stromal cells (MSCs) are found in adult tissues such as bone marrow and are able to differentiate into bone, cartilage and fat tissues. Read more
Role of RNA-DNA hybrids and transcription-replication conflicts in colorectal cancer
Replication stress, or replication-associated DNA damage, occurs frequently in cancer. There is a growing interest in targeting oncogene-induced replication stress for cancer therapy. Read more
Investigating the role of the microenvironment in paediatric and adult acute myeloid leukaemia
The incidence of acute myeloid leukaemia (AML) increases with age, and in childhood accounts for 20% of all leukaemia. The current overall survival rate in children is only 60-70%, and thereafter falls progressively with age to 5-15% in the elderly. Read more
Exploring the role of matrix encapsulation on early developmental decisions using non-animal sourced hydrogels
A PhD studentship in stem cell biology and disease modelling is available in Prof Merry’s group (. https://www.nottingham.ac.uk/medicine/people/cathy.merry. Read more
Last chance to apply
Therapeutic opportunities emerging from studies of immune checkpoints
Our focus has been on the cell biology of the T-cell surface. Read more
Last chance to apply
Therapeutic opportunities emerging from studies of immune checkpoints
Our focus has been on the cell biology of the T-cell surface. Read more
4-year PhD Studentship: Investigating PZ-128 as a novel treatment for nephrotic syndrome and diabetic nephropathy
Idiopathic Nephrotic Syndrome (INS) is a devastating disease in children that is typically associated with oedema, proteinuria, hypertension, microscopic haematuria, and renal insufficiency and usually leads to end stage renal failure despite the use of prolonged and toxic immunosuppression. Read more
Characterization of the molecular mechanisms of breast cancer metastasis to bone: from basic research to biomarkers
About the Project. Breast cancer is responsible for over 300,000 cancer diagnoses within the UK per annum, and it is estimated that one in 7 women will develop breast cancer. Read more
Tissue mechanics: A driver of pathogenesis in B-cell non-Hodgkin’s lymphomas (B-NHL) and a therapeutic opportunity?
Applications will be reviewed until a suitable candidate is appointed. You will be working as part of a highly motivated team in the haematology section of the cancer medicine department; many of our past student have entered a career in academic haematology, or medical research. Read more
Protein degradation-based gene therapies for neurodegenerative disease
Proteins fold like origami into complex three-dimensional shapes. This process can malfunction and result in misfolded proteins that stick together to form large aggregates. Read more
EPSRC CDT in Bioprocess Engineering Leadership: Complex Biological Products Manufacture
Biological products and their manufacture are progressing to unparalleled levels of complexity. Examples include engineered biocatalysts, antibody-drug conjugates, multivalent vaccines and cellular therapies. Read more
Last chance to apply
Epigenetic regulation of cholangiocarcinoma growth
Cholangiocarcinoma (CCA) is a rare malignant bile duct tumour with an average incidence of 1/100,000 in the population per year. The overall incidence of CAA includes 15% of primary liver cancers, the second most common type of primary liver cancer. Read more
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