Vitamin D3 deficiency is a common public health problem worldwide that is increasingly believed to contribute not only to decreased bone mineralisation but potentially to other serious medical conditions. Read more
The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks. Read more
Heart failure is the most common cause of mortality in diabetes patients, but current diabetes therapies have a limited impact on the incidence of heart failure in diabetic populations. Read more
Cilia are hair-like structures that project from the surface of cells and act as “cellular antennae,” sensing and relaying information from the environment. Read more
Staphylococcus aureus and Candida albicans are commensal microbes which can become pathogenic and cause serious illness, especially in hospitalised patients. Read more
Proteomic approaches using mass spectrometric analysis have proved a valuable tool in understanding the molecular pathogenesis of complex disorders such as schizophrenia and ASD. Read more
A primary goal in regenerative medicine is to identify and implement novel treatments aimed at improving our ability to regenerate injured, diseased or aged tissues and organs, including the heart. Read more
Phosphoinositide lipids (PIPs) play critical roles in development and the homeostasis of adult tissues and their dysfunction has been linked to major human diseases such as cancer, diabetes, myopathies and neuropathies. Read more
Aggregation of aberrant proteins is a hallmark in age-related neurodegenerative diseases. These aggregates cause cell death and tissue degeneration leading to loss of function, hence strategies to reduce aggregation are necessary for delaying disease onset and progression. Read more
Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events 1. Read more
The emergence of bacteria that are resistant to available antibiotics represents an enormous and growing global threat requiring new targets and strategies to combat infection. Read more
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. Read more
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