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Aberdeen University Biochemistry PhD Projects, Programs & Scholarships

We have 14 Aberdeen University Biochemistry PhD Projects, Programs & Scholarships

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Showing 1 to 14 of 14
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Developing an enzymatic toolbox to make complex modified peptides
  Prof M Jaspars, Dr W Houssen, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

The pharmaceutical industry has identified a major gap in its portfolio. On the one hand, they are excellent at discovering small molecules that act via a lock and key type mechanism.
  Discovery of novel pharmaceuticals from marine and desert microorganisms
  Prof M Jaspars, Dr R Ebel
Applications accepted all year round

Funding Type

PhD Type

Microorganisms from extreme environments such as the deep seas, cold seas and hyper arid deserts have been shown to produce a range of complex natural products with high biological activity.
  Genome mining of novel antimicrobial natural products from new bacterial strains
  Dr H Deng, Prof M Jaspars
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  QUADRAT DTP: Impact of climate change on stability of sponge-microbe symbiosis
  Dr C Gubry-Rangin, Prof M Emmerson
Application Deadline: 29 January 2020

Funding Type

PhD Type

This project aims to understand the biodiversity and stability (resilience and resistance) of sponge-microbe symbiosis following multiple environmental perturbations influenced by climate change.
  QUADRAT DTP: Modelling metagenomics-derived microbial traits in soils under climate change
  Dr A Malik, Dr T Caruso
Application Deadline: 29 January 2020

Funding Type

PhD Type

Background. Microorganisms are critical in terrestrial carbon cycling because their growth and activity largely control the fate of recent plant carbon inputs as well as protected soil organic carbon (SOC).
  Combining omega-3 docosahexaenoic acid and melatonin to manage spinal cord injury-induced central neuropathic pain.
  Dr W Huang, Prof H Galley
Application Deadline: 29 February 2020

Funding Type

PhD Type

About half of spinal injury patients develop neuropathic pain, which is driven by neuroinflammation, has no effective treatments, and impacts significantly on daily functioning.
  Exploiting the endocannabinoid system in chronic lymphocytic leukaemia
  Dr F Murray, Dr J Hislop, Prof R Pertwee, Prof M A Vickers
Application Deadline: 17 February 2020

Funding Type

PhD Type

Endocannabinoids, such as anandamide and 2-arachidonoyl glycerol, are endogenous cannabinoids produced in mammalian tissues that are anti-proliferative, anti-metastatic and pro-apoptotic in lymphoma and leukaemia.
  Identifying the determinants of tumour susceptibility to replication-inhibiting chemotherapy
  Prof A Donaldson, Dr S R Dundas
Application Deadline: 17 February 2020

Funding Type

PhD Type

Chromosome replication and maintenance are central for cell division, and derailment of these processes is a major cause of cancer.
  Impact of the immune landscape on androgen ablation therapy and progression to therapy-resistant disease
  Prof I McEwan, Prof H M Wilson, Dr S R Dundas
Application Deadline: 17 February 2020

Funding Type

PhD Type

Prostate cancer is the most commonly diagnosed cancer in men and is a leading cause of cancer related death. The androgen receptor is important for the development and function of the prostate gland and is a driver of prostate cancer progression and metastasis.
  In Silico design and chemoenzymatic synthesis of bioactive cyclic and stapled peptides
  Dr W Houssen, Dr S Dall'Angelo, Dr G S Bewick
Application Deadline: 24 January 2020

Funding Type

PhD Type

Cyclic and modified cyclic peptides are very appealing scaffolds especially as therapeutics with several examples reach the clinic e.g.
  Investigating a parasite-specific gene expression mechanism for the identification of novel anthelmintic drug targets
  Dr B Mueller, Dr J Pettitt, Dr B Connolly
Application Deadline: 13 March 2020

Funding Type

PhD Type

Nematode parasites remain a major cause of neglected human disease and make significant global impacts on the health of agriculturally important animals and plants.
  The mechanism of DNA organisation mediated by cohesion and condensin
  Dr B Hu, Prof A Donaldson
Application Deadline: 13 March 2020

Funding Type

PhD Type

The DNA of all organisms must be compacted in order to store a large amount of genetic information in one cell. Compaction must be regulated to allow access of DNA replication or transcription machinery, but to enable suitable condensation for effective chromosome segregation into two daughter cells at mitosis.
  What determines tumour susceptibility to replication-inhibiting chemotherapy?
  Prof A Donaldson, Dr S R Dundas
Application Deadline: 13 March 2020

Funding Type

PhD Type

Chromosome replication and maintenance are central for cell division, and derailment of these processes is a major cause of cancer.
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