University Hospital Essen
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Biochemistry PhD Projects, Programmes & Scholarships
We have 477 Biochemistry PhD Projects, Programmes & Scholarships
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3 PhD positions avaliable within the DFG-funded Clinical Research Unit PhenoTImE (CRU 337-2)
The University Hospital Essen offers first class medical services in the Ruhr metropolis. Every year,. 225.000 patients are treated in 30 clinics, 27 institutes and specialized centers. Read more
Elucidating the molecular pathways through which an unhealthy diet contributes to sight loss.
Lead Institute / Faculty. Clinical and Experimental Sciences/Medicine. Main Supervisor. Dr J. Arjuna Ratnayaka. Other members of the supervisory team. Read more
Sustainable fuels and chemicals from sustainable biomass and bioprocessing
Canterbury Christ Church University School of Engineering, Technology and Design welcomes applications to its PhD course from self-funded applicants to study a range of PhD projects. . Read more
Exploring the Molecular Mechanism of Novel Mitochondrial Neurotoxins identified through a Machine Learning Approach
Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events 1. Read more
Identifying novel regulators of haematopoiesis using flies
Supervisors. Iwan Evans (primary supervisor); Steve Brown (Biosciences, secondary supervisor). Project details. Control of blood cell proliferation, survival and activation is critical to the health of an organism. Read more
Meals for macrophages – investigating how macrophages engulf and process dying cells in vivo
Supervisors. Iwan Evans (primary supervisor); Phil Elks and Simon Johnston (secondary supervisors). Project details. A critical role for phagocytic cells such as macrophages is the engulfment and subsequent degradation of dying cells and debris. Read more
Investigating the control and function of macrophage subtypes using Drosophila melanogaster
Supervisor(s). Iwan Evans (Primary Supervisor, IICD) and Martin Zeidler (Second Supervisor, Biosciences). Project details. The phagocytic white blood cells known as macrophages are a highly heterogeneous population of cells. Read more
Noise-induced transitions in gene regulatory networks
Our world is full of noise sources at different spatial and temporal scales. The temperature and sunlight changes day to night. A receptor protein interacts with its target molecule undergoing Brownian motion. Read more
The interplay between ethnicity, the microbiome and DNA damage in prostate cancer
In the UK, black men are at greater risk of prostate cancer and have a higher mortality rate compared to Caucasian and Asian men. Read more
Disruption of nuclear envelope regulation of miRNA, enhancer, and gene loci positioning leads to aberrant development and disease
Research Group:
Institute of Cell Biology
Defects in spatial genome organisation are linked to human disease and it is speculated that most as yet unidentified disease alleles will occur in non-coding genome regions. Read more
Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation
Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more
Regulation and mechanics in polarity
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more
Is there a Role for Activated Akt in Palatogenesis?
Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more
Studying novel histone acylations in the regulation of gene expression
Title of the project. Studying novel histone acylations in the regulation of gene expression. Project summary. In the nucleus of eukaryotes, DNA wraps around octamers of histone proteins to form a structure called chromatin. Read more
Investigating the effects of host-pathobiont interactions on inflammation resolution in chronic inflammatory disease
Host-microbiota homeostasis is pertinent for the maintenance of a healthy state. Chronic inflammatory diseases, which are often linked, such as rheumatoid arthritis (RA) or cardiovascular disease, are characterised by disturbances on both sides. Read more