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Biochemistry (genomic) PhD Projects, Programmes & Scholarships
We have 35 Biochemistry (genomic) PhD Projects, Programmes & Scholarships
We have 35 Biochemistry (genomic) PhD Projects, Programmes & Scholarships
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Investigating the impact of the mechanical code of the genome on protein:DNA interactions
Training opportunity. This project will appeal to a motivated student who wants training in the cutting-edge technologies surrounding genomic research. Read more
A Multi-Omics approach to understanding cardiovascular risk in patients with End-Stage Kidney Disease
Background. End-stage Kidney failure, also known as End-Stage Kidney Disease (ESKD), is the final, irreversible stage of chronic kidney disease (CKD), where kidney function has worsened to the point that the kidneys can no longer function independently. Read more
3D genome folding and its role in DNA-based processes
The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more
Deciphering the landscape of nucleoporin and lamin function in nucleocytoplasmic communication, nuclear scaffolding and transcriptional control in disease prevention
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
Deciphering the landscape of nucleoporin and lamin function in nucleocytoplasmic communication, nuclear scaffolding and transcriptional control in disease prevention
The nucleus has an instrumental role in cellular responses by coordinating shuttling of components in and out of the nucleus and gene expression with genome architecture and stability. Read more
Self-funded project: Uncovering the biological roles of recently discovered carbohydrate-active enzymes in green microalgae.
Photosynthetic microalgae are microbes that have colonized every habitat on Earth, and are paramount in fueling the global ocean biological carbon pump. Read more
Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
Research Group:
BBSRC MIBTP
Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017). Read more
Does membrane repair fail to alert the immune system to disease?
The cGAMP-synthase cGAS recognises microbial or self-DNA to activate STING and induce the release of pro-inflammatory molecules. But cytoplasmic DNA is also particularly abundant in cancer cells, under the form of genomic structures called ‘micronuclei’. Read more
Evolution of vertebrate blood vessels
The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks. Read more
Role of APC/C subunit post-translational modifications on the function of the APC/C in mitosis
The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more
Transcription factor complexes in Acute Myeloid Leukaemia
Acute Myeloid Leukaemia (AML) is a group of blood cancers, resulting from uncontrolled cellular proliferation of cells belonging to the myeloid lineage. Read more
TYLERK_U23MED - Functional Genomics and Metagenomics of Cryptosporidiosis
Human cryptosporidiosis is the leading protozoan cause of diarrhoeal mortality worldwide, and most infection is caused by either person to person transmitted Cryptosporidium hominis or the presumptively zoonotic C. Read more
Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
Research Group:
School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more
Saving the planet through carbon recycling: engineering bacterial capture of gasified waste for bioplastics production
Climate change caused by the release of greenhouse gases from fossil fuels and through change of land use threatens life on our planet. Read more
Nutritional enhancement of fruits and vegetables
Background. A wealth of scientific evidence now exists to show that diets rich in fruits and vegetables are beneficial to human well-being and health [1]. Read more