The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

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(MRC DTP CASE) Development of new in vitro infection models to tackle antimicrobial resistance

The University of Manchester Faculty of Biology, Medicine and Health

Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. Read more

Supervisors: Dr S Gago, Dr M Bertuzzi, Dr J Bella

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health

We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more

Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

The University of Manchester Faculty of Biology, Medicine and Health

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Supervisors: Prof D Brough, Dr K Couper

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health

Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more

Supervisors: Dr A Politis, Dr CP Pliotas

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry

A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more

Supervisor: Prof A Green

31 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Building Enzymes with New Catalytic Functions & Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry

A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more

Supervisor: Prof A Green

31 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

The University of Manchester Department of Chemistry

Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more

Supervisors: Dr S Lovelock, Dr C Markin

31 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health

RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more

Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar

Year round applications PhD Research Project Self-Funded PhD Students Only

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Geomicrobiological controls on radionuclide speciation and fate during the geodisposal of radioactive waste

The University of Manchester Department of Earth and Environmental Sciences

Context. The UK has been generating electricity from nuclear power for over sixty years. Consequently, the safe disposal of the UK’s existing ~750,000 m3 of radioactive waste is a clear priority. Read more

Supervisors: Prof J Lloyd, Prof S Shaw, Dr A Uknnl

30 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Sustainable Commodity Chemicals through Enzyme Engineering & Design (SuCCEED) - 4 posts available

The University of Manchester Department of Chemistry

SuCCEED is a BBSRC-funded Prosperity Partnership multi-million project between The University of Manchester and Shell. Commodity chemicals are produced on a global scale and normally derived from finite geological sources. Read more

Supervisors: Dr N Dixon, Dr J Esteban Serrano, Prof A Green, Prof D Leys, Dr V Spallina, Prof M Turner, Dr J Winterburn

30 June 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes

The University of Manchester Faculty of Biology, Medicine and Health

A self-funded PhD studentship is available in the laboratories of Andrew McBain, Stefan Meyer and Chris Knight. The project aims to study the microbiome in paediatric cancer predisposition and chromosomal instability syndromes (CIS). Read more

Supervisors: Prof A McBain, Dr S Meyer, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

The University of Manchester Department of Physics and Astronomy

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Supervisor: Prof J Lu

28 June 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

The University of Manchester Department of Chemistry

Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more

Supervisor: Dr C Megarity

30 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Alternative Materials and Processes for the Textile and Fashion Industry

The University of Manchester Department of Materials

The fashion and textile industries conduct some of the most polluting practices on the planet. Many initiatives are striving to positively impact the issues the industry faces, in line with climate targets and UN sustainable development goals. Read more

Supervisor: Dr J Wood

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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(University of Manchester - University of Tokyo Dual Award) Diversifying Antitumor Drugs through the Integration of Synthetic Biology and Chemo-enzymatic Approaches

The University of Manchester Department of Chemistry

Ecteinascidin 743 (ET-743, Trabectedin) is a marine-derived natural organic compound approved for the treatment of soft tissue sarcomas. Read more

Supervisors: Prof E Takano, Prof H Oguri

29 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry

Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more

Supervisor: Prof S Hay

27 October 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Characterising human sebum using NMR approaches

The University of Manchester Department of Chemistry

We have recently shown that skin secretions in particular sebum, has a critical diagnostic role in other diseases unrelated directly to the skin. Read more

Supervisors: Dr D K Trivedi, Prof M Nilsson, Prof GA Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics

The University of Manchester Department of Chemistry

Plastics are a broad range of solid polymeric materials that have found widespread application globally. However, there has been a steady accumulation of discarded plastics and there is now growing awareness that they present a significant hazard to the natural environment and human health. Read more

Supervisor: Dr L Wong

Year round applications PhD Research Project Self-Funded PhD Students Only

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Unlocking the potential of plant cellulose for the production of new materials and chemicals

The University of Manchester Faculty of Biology, Medicine and Health

Plant biomass, in the form of plant cell walls are the only renewable resource sufficiently abundant to make a meaningful contribution to decreasing CO. Read more

Supervisors: Prof S Turner, Dr J Pittman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more

Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health

Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more

Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health

Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more

Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health

The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more

Supervisors: Prof CN O'neill, Prof A McBain

Year round applications PhD Research Project Self-Funded PhD Students Only

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Viral-surface interactions studied by vibrational sum-frequency spectroscopy

The University of Manchester Department of Materials

The recent COVID-19 pandemic, and in particular fomite transmission of the virus, led to a lot of interest in how viral particles attached to surfaces, their survival times on different materials and how they transferred to hosts. Read more

Supervisors: Dr A Thomas, Dr R Lindsay

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding and preventing the denaturation of proteins on surfaces in manufacture, storage and delivery of biotherapeutics

The University of Manchester Department of Materials

Protein and peptide therapeutics are pharmaceutical drug treatments derived from natural sources. They are applied to a range of diseases from diabetes to novel cancer therapies. Read more

Supervisors: Dr A Thomas, Prof A Saiani

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health

Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more

Supervisors: Prof G D Pavitt, Dr A Roseman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Engineering Ice-Binding Proteins

The University of Manchester Department of Chemistry

Ice-binding proteins are produced by extremophiles to help them survive in the worlds coldest places. They have many potential applications, from the storage of cells/tissue to transport infrastructure. Read more

Supervisor: Prof m Gibson

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 41 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

We have 41 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

(MRC DTP CASE) Development of new in vitro infection models to tackle antimicrobial resistance

(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

Design and Evolution of Enzymes with New Catalytic Functions

Building Enzymes with New Catalytic Functions & Design and Evolution of Enzymes with New Catalytic Functions

High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

Geomicrobiological controls on radionuclide speciation and fate during the geodisposal of radioactive waste

Sustainable Commodity Chemicals through Enzyme Engineering & Design (SuCCEED) - 4 posts available

Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

Alternative Materials and Processes for the Textile and Fashion Industry

Understanding the role of spliceosome gene mutations in disease

(University of Manchester - University of Tokyo Dual Award) Diversifying Antitumor Drugs through the Integration of Synthetic Biology and Chemo-enzymatic Approaches

New Methods for modelling cofactor-dependent enzyme structure and function

Characterising human sebum using NMR approaches

Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics

Unlocking the potential of plant cellulose for the production of new materials and chemicals

Driving phenotypic plasticity and metastasis in small cell lung cancer

Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The role of nuclear localisation of adhesion proteins in tumour growth and invasion

Defining the molecular mechanisms of leukaemia chemotherapies

Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

Viral-surface interactions studied by vibrational sum-frequency spectroscopy

Understanding and preventing the denaturation of proteins on surfaces in manufacture, storage and delivery of biotherapeutics

Chaperones and the response to protein misfolding stress

Investigating the interaction of La related proteins with colliding ribosomes

Engineering Ice-Binding Proteins

We have 41 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

We have 41 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

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