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We have 23 Biochemistry (enzyme) PhD Projects, Programmes & Scholarships for UK Students

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Biochemistry (enzyme) PhD Projects, Programmes & Scholarships for UK Students

We have 23 Biochemistry (enzyme) PhD Projects, Programmes & Scholarships for UK Students

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Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

The University of Manchester Department of Chemistry
Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more
 Supervisor: Dr C Megarity
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry
Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more
 Supervisor: Prof S Hay
 27 October 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Sustainable Commodity Chemicals through Enzyme Engineering & Design (SuCCEED) - 4 posts available

The University of Manchester Department of Chemistry
SuCCEED is a BBSRC-funded Prosperity Partnership multi-million project between The University of Manchester and Shell. Commodity chemicals are produced on a global scale and normally derived from finite geological sources. Read more
 Supervisors: Dr N Dixon, Dr J Esteban Serrano, Prof A Green, Prof D Leys, Dr V Spallina, Prof M Turner, Dr J Winterburn
 30 June 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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New enzymatic routes for the synthesis of peptide therapeutics

The University of Manchester Department of Chemistry
Peptides are essential in life and are widely used as therapeutic agents, vaccines, biomaterials and in other important applications. Read more
 Supervisor: Prof J Micklefield
 19 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry
A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more
 Supervisor: Prof A Green
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Building Enzymes with New Catalytic Functions & Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry
A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more
 Supervisor: Prof A Green
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

The University of Manchester Department of Chemistry
Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more
 Supervisors: Dr S Lovelock, Dr C Markin
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry
Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more
 Supervisors: Dr PA Ash, Dr H Kwon
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology
Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more
 Supervisors: Dr C Jenul, Prof D Jones
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences
Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more
 Supervisors: Dr H O'Hare, Dr N Garton
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding the roles of triacylglycerol in modulating mycobacterial growth and biophysical properties

University of Leicester Department of Respiratory Sciences
Mycobacteria contain more lipid than any other bacteria. In addition to a characteristically lipid-rich cell envelope, mycobacteria can accumulate triacylglycerol (TAG) as cytoplasmic lipid bodies (LBs). Read more
 Supervisors: Dr N Garton , Dr G Mukamolova
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry
Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more
 Supervisors: Dr RD Doveston, Prof S Macip
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more
 Supervisors: Dr HZ Zhou, Dr J Meng, Prof F Muntoni
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Fully funded BBSRC CTP with Unilever PhD in Biology : Revealing the roles of the anaerobic skin microbiome in malodour production

University of York Department of Biology
Lead supervisor: Prof. Gavin Thomas (UofY Biology). Co-Supervisor: Prof Tony Wilkinson (UofY Chemistry), Dr Alan Cartmell (UofY Biology) and Dr Barry Murphey (Unilever). Read more
 Supervisor: Prof G H Thomas
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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