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We have 45 Bioinformatics (drug) PhD Projects, Programmes & Scholarships

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Bioinformatics (drug) PhD Projects, Programmes & Scholarships

We have 45 Bioinformatics (drug) PhD Projects, Programmes & Scholarships

Fully funded PhD studentship in mechanisms of cancer heterogeneity and drug sensitivity

Treatment of cancer with drugs that cause DNA damage often leads to development of the drug tolerance. Recently, we uncovered a novel mechanism of such an adaptation that associates with active generation of hundreds of thousand mutations in chromosomes that prevent drug-triggered DNA damage. Read more

Predicting drug solubility in different solvents using molecular simulation and machine learning

Predicting the solubility of complex drug-like molecules is crucial at several stages of the drug discovery and manufacture. In particular, solvent selection has been highlighted as a crucial step in process design and optimisation [1]. Read more

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Transcriptome biomarkers and mechanisms of chemoresistance

Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more

SLS SF1: Investigating the basis of invasive multi-drug resistant Salmonella Dublin

Salmonella Dublin belongs to non-typhoidal Salmonella that primarily causes self-limiting gastrointestinal illness in humans; however, it has adapted to cause invasive disease and life-threatening infections, especially in elderly people, children, and immunocompromised individuals. Read more

Identify novel approaches to combat multi drug resistant pathogens

Our research is focused on recalcitrant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, andEnterobacter species) pathogens; especially hard-to-treat clinical isolates involved in multidrug resistance, biofilm infections and persistence. Read more

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