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We have 59 Bioinformatics (genetics) PhD Projects, Programmes & Scholarships

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Bioinformatics (genetics) PhD Projects, Programmes & Scholarships

We have 59 Bioinformatics (genetics) PhD Projects, Programmes & Scholarships

Genetic causes of novel neurodevelopmental disorders

The Rare Disorder Genetics / Bicknell lab is interested in characterising novel genetic syndromes, with three core motivations. -the difference we can make to families with rare disorders, through providing them with more information. Read more

Novel disease genes in brain development and decline

The Rare Disorder Genetics / Bicknell lab is interested in characterising novel genetic syndromes, with three core motivations. -the difference we can make to families with rare disorders, through providing them with more information. Read more

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness

Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more

Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment

The optic nerve is a special sensory nerve that transmits visual impulses from the retina to the brain. Primary Open Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin that affects 1 in 10 elderly individuals. Read more

Genetics: Genetic studies of developmental eye disorders to investigate genotype-phenotype correlations

Developmental eye defects that affect the front of the eye give rise to a spectrum of congenital ocular phenotypes that affect the cornea, lens, iris, trabecular meshwork or the globe itself. Read more

Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more

Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Engineering plant microbiome PhD: Exploring and engineering the plant microbiome for increased resilience

Title. Exploring and engineering the plant microbiome for increased resilience. Project Description. Plants are impacted by numerous abiotic and biotic factors above and below ground, such as nutrient availability, local climatic conditions, and the surrounding fauna. Read more

Using nutrigenetic, nutrigenomic and machine learning approaches to investigate the risk of cardiometabolic disease-related traits in ethnically diverse populations.

This PhD project represents an exciting opportunity to develop and conduct research at the forefront of nutritional and genetic epidemiology, contributing to the prediction, prevention, and better understanding of the development of non-communicable diseases such as obesity and diabetes, using datasets from multiple ethnic groups. Read more

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