Bioinformatics (in vivo) PhD Projects, Programmes & Scholarships

We have 30 Bioinformatics (in vivo) PhD Projects, Programmes & Scholarships

Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

Supervisors: Dr G Mavria, Dr S Bell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health

Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more

Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Molecular mechanisms underlying the anti-atherogenic actions of natural products

Cardiff University Cardiff School of Biosciences

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for most deaths in the western world with mortality increasing at a marked rate in developing. Read more

Supervisors: Dr D Ramji, Dr T Hughes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

University of Leeds Faculty of Medicine and Health

Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more

Supervisors: Prof M Wilcox, Prof A O'Neill, Dr J Freeman, Dr I Moura

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Repurposing drugs as new treatments for breast cancer

University of Leeds Faculty of Medicine and Health

Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more

Supervisors: Dr L Matthews, Dr P Meakin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

University of Leeds Faculty of Medicine and Health

Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more

Supervisors: Prof M Wilcox, Dr K Davies, Dr A Buckley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction

University of Liverpool Institute of Life Course and Medical Sciences

Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more

Supervisor: Dr D Wilkinson

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of MicroRNAs in neurodegenerative diseases

University of Birmingham Institute of Inflammation and Ageing

We are seeking talented, motivated students with a passion for research in Neuroscience and Neurotrauma to join the team led by Dr Valentina Di Pietro (Dr Valentina Di Pietro - Institute of Inflammation and Ageing - University of Birmingham). Read more

Supervisor: Dr V P Di Pietro

Year round applications PhD Research Project Self-Funded PhD Students Only

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Competition and cooperation relationships within human microbial communities.

University of Nottingham School of Life Sciences

Typical studies of the human microbiome identify dysbiosis by sampling from healthy individuals, comparing them to individuals with a particular disease state, and reporting changes in the presence and/or abundance of bacterial species. Read more

Supervisors: Dr F Whelan, Dr K Hardie

Year round applications PhD Research Project Self-Funded PhD Students Only

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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Investigating the role of Aquaporins in age related diseases

University of Liverpool Institute of Life Course and Medical Sciences

Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more

Supervisor: Dr C Staunton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Manipulation of neuroimmune responses and behaviour by infectious agents

University of Leeds Faculty of Biological Sciences

This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more

Supervisors: Dr G Mcconkey, Dr S Clapcote

Year round applications PhD Research Project Self-Funded PhD Students Only

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From bench to pre-clinical evaluation: a novel nucleic acid vaccine targeting tumour-associated antigens

Royal College of Surgeons in Ireland Molecular and Cellular Therapeutics

Cancer and the long-term toxicities sustained from treatment remain a public health issue for adult and paediatric patients. The spread of tumour cells is believed to account for up to 90% of cancer-related morbidities. Read more

Supervisor: Dr O Piskareva

1 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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We have 30 Bioinformatics (in vivo) PhD Projects, Programmes & Scholarships

Bioinformatics (in vivo) PhD Projects, Programmes & Scholarships

We have 30 Bioinformatics (in vivo) PhD Projects, Programmes & Scholarships

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