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Bioinformatics (recombinant) PhD Projects, Programs & Scholarships

We have 16 Bioinformatics (recombinant) PhD Projects, Programs & Scholarships

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  Modelling cellular stress during recombinant protein production for improving upstream biomanufacturing processes
  Dr D Dikicioglu, Prof G Lye
Application Deadline: 29 November 2019

Funding Type

PhD Type

Applications are invited for one PhD studentship to work in modelling the stress imposed on host organisms by recombinant protein production for improving predictive capabilities of upstream bioprocess models employed in biomanufacturing practices.
  Investigating the Drosophila DF31 protein to gain insight into the mechanisms and chromatin maintenance in animal cells
  Dr S Cotterill, Dr A Nohturfft
Applications accepted all year round

Funding Type

PhD Type

The Drosophila DF31 protein is an abundant ribonucleoprotein that localises to euchromatic regions and is involved in maintaining chromosome structure.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
  Prof A Sharrocks, Prof M Rattray
Applications accepted all year round

Funding Type

PhD Type

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  EASTBIO: The role of secreted tumour suppressor SPZ1 in Papillomavirus E7-mediated oncogenesis
  Prof J Haas, Dr K Cuschieri
Application Deadline: 5 January 2020

Funding Type

PhD Type

Deanery of Biomedical Sciences. Currently, 112 different non-human papillomavirus (PV) types are known, which have been isolated from a broad range of 54 host species including cattle, canines, horses, rodents, bats, dolphins and primates.
  An extended histone code at bivalent domains and its role in poising developmental genes in embryonic stem cells
  Research Group: Institute of Cell Biology
  Dr P Voigt
Application Deadline: 5 January 2020

Funding Type

PhD Type

Histone modifications play key roles in the regulation of gene expression. In embryonic stem cells, promoters of developmental genes simultaneously carry histone H3 lysine 4 trimethylation (H3K4me3), which is usually found at active promoters, and H3K27me3, a hallmark of repressive chromatin.
  Development of a synthetic platform to derive small antibodies against user-defined ligands
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr E Cachat, Prof S Rosser
Application Deadline: 5 January 2020

Funding Type

PhD Type

Advances in recombinant antibody technologies have greatly facilitated the development of novel antibody formats such as single-chain variable fragments (ScFvs) [1] and single domain nanobodies [2].
  Precision Medicine DTP - Connecting Molecular Profiles to Phenotype: A Proteomic Resource for Assigning Cell Cycle and Senescent States
  Research Group: Institute of Cell Biology
  Dr T Ly, Dr A Lindqvist
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. A hallmark of cancer is aberrant cell cycle control leading to pathological cell proliferation. Cell cycle progression is controlled by key kinases, such as cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs).
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