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We have 15 Bioinformatics (transcription) PhD Projects, Programmes & Scholarships

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Bioinformatics (transcription) PhD Projects, Programmes & Scholarships

We have 15 Bioinformatics (transcription) PhD Projects, Programmes & Scholarships

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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Transcriptional kinases in cancer and developmental disorders

University of Leicester Molecular and Cell Biology
Cyclin-dependent kinases (CDKs) are protein kinases performing essential functions in regulation of cell cycle and transcription. Read more
 Supervisor: Dr MT Tellier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
 Supervisor: Prof U Klein
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology
Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more
 Supervisors: Dr MT Tellier, Dr Y Markaki
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

University of Leicester Department of Genetics and Genome Biology
General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more
 Supervisors: Dr B Warren, Dr E Rosato, Dr R Feuda
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health
Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more
 Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Transcriptome homeostasis in cellular ageing and cancer

Queen Mary University of London Institute of Dentistry
Project Summary. We have previously established the oncogenic mechanisms of the transcription factor FOXM1 in perturbation of genome stability (1, 2), epigenome (3, 4) and adult progenitor epithelial stem cell proliferation (5). Read more
 Supervisor: Dr M T Teh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded MSc R- The mechanisms driving heterogeneity and stemness during cellular transformation.

University of Bristol School of Cellular and Molecular Medicine
The mechanisms driving heterogeneity and stemness during cellular transformation. Read more
 Supervisor: Dr A Essafi
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded PhD- The mechanisms driving heterogeneity and stemness during cellular transformation.

University of Bristol School of Cellular and Molecular Medicine
The mechanisms driving heterogeneity and stemness during cellular transformation. Read more
 Supervisor: Dr A Essafi
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of RNA secondary structure in plant transposable elements

Durham University Department of Biosciences
Transposable elements (TEs), often referred to as jumping genes, are mobile genetic elements that can be found ubiquitously across the tree of life. Read more
 Supervisor: Dr J Cho
 17 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Using machine learning to predict cell-type specific effects of genetic variants which influence genome regulation

Imperial College London Department of Brain Sciences
UK Dementia Research Institute (UK DRI) Centre at Imperial. PhD Studentship in Machine Learning for Genomics. Imperial College London, White City Campus, London, UK. Read more
 Supervisor: Dr N Skene
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Using machine learning to predict cell-type specific effects of genetic variants which influence genome regulation

Imperial College London Department of Brain Sciences
UK Dementia Research Institute (UK DRI) Centre at Imperial. PhD Studentship in Machine Learning for Genomics. Imperial College London, White City Campus, London, UK. Read more
 Supervisor: Dr N Skene
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health
Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more
 Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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