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Bioinformatics (animal disease) PhD Projects, Programs & Scholarships

We have 30 Bioinformatics (animal disease) PhD Projects, Programs & Scholarships

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  Precision Medicine DTP – Integration of single-cell RNA sequencing data from human and murine kidney disease to identify novel therapeutic targets
  Research Group: Centre for Cardiovascular Science
  Dr BC Conway, Dr T Chandra, Dr D Ferenbach
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease and for end-stage kidney disease (ESRD), at which point patients require dialysis or transplantation.
  Wellcome Trust funded four-year PhD programme in ‘One Health Models of Disease: Science, Ethics and Society’

Funding Type

PhD Type

Edinburgh Infectious Diseases, with the Centre for Biomedicine, Self and Society, is delighted to open applications to the first cohort of students on this new Wellcome Trust funded four-year PhD programme.
  EASTBIO: Novel approaches to improving calf health: new technology and data analytics
  Dr M Haskell, Dr C Duthie
Application Deadline: 5 January 2020

Funding Type

PhD Type

Maintaining good calf health is important for both the productivity and sustainability of farming enterprises. A report by the Cattle Health and Welfare Group (GB)) showed that 3.6% of dairy bull calves and 2.5% of dairy heifer calves died under 1 month of age.
  Precision Medicine DTP - Genomic analysis of the impact of sexual recombination on the segregation of virulence genes in African trypanosomes
  Research Group: The Roslin Institute
  Dr L Morrison, Dr A MacLeod, Dr J Prendergast
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. African trypanosomes are vector-borne protozoa that cause serious human and animal disease across sub-Saharan Africa.
  Precision Medicine DTP - 3D Modeling of Changes in Genome Architecture in Development and Disease
  Research Group: Institute of Cell Biology
  Prof E Schirmer, Dr D Marenduzzo
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Defects in spatial genome organisation have recently been linked to human disease and the National Institutes of Health, USA director speculated that most as yet unidentified disease alleles will occur in non-coding genome regions.
  Engineering de novo microscopic ecologies to monitor and dissect disease spread
  Dr T Gorochowski, Dr S English
Application Deadline: 6 January 2020

Funding Type

PhD Type

Understanding what regulates the spread of diseases in space and time is critical if we are to combat them effectively.
  MRC DiMeN Doctoral Training Partnership: Replacing deficient microglia in the developing brain: using a zebrafish model of human leukodystrophy to test new therapies
  Dr N Hamilton, Dr A J Grierson
Application Deadline: 6 January 2020

Funding Type

PhD Type

RNASET2-deficient leukodystrophy is a heritable white matter disorder affecting infants and characterised by severe psychomotor impairments.
  Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1
  Dr T Millard, Dr S Banka
Applications accepted all year round

Funding Type

PhD Type

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene.
  Functional role of transcript diversity in salmon immunity: development of full-length RNA sequencing
  Dr D Macqueen, Dr D Robledo
Application Deadline: 10 January 2020

Funding Type

PhD Type

Disease is a pressing challenge to the sustainability of fish farming, causing huge economic loss, environmental issues, animal welfare problems, and reputational harm to industry.
  (BBSRC DTP) Functional and structural analysis of RBBP5: a histone tail modifier essential for development, disease and healthy ageing
  Dr G Poulin, Prof A Sharrocks, Dr A J Whitmarsh
Application Deadline: 31 January 2020

Funding Type

PhD Type

The genome is the blueprint of any living system. However, it is the regulation of gene expression that enables life. For transcription to take place, the molecular machinery involved has to access genomic DNA.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
  (BBSRC DTP) Cardiac Physiology in the World’s Oldest Vertebrate, The Greenland Shark
  Dr H Shiels, Dr G Galli
Application Deadline: 31 January 2020

Funding Type

PhD Type

The life span of the Greenland shark is at least 272 years and may be as long as 500 years making this animal the longest living vertebrate on the planet1.
  (BBSRC DTP) The role of clock dysfunction in obesity-related inflammation and insulin resistance
  Dr D Bechtold, Dr S Cruickshank, Dr I Iqbal
Application Deadline: 31 January 2020

Funding Type

PhD Type

Obesity is one of the biggest challenges to public health in the UK and across much of the world. The major threat is in obesity-related metabolic disturbances, which drive insulin resistance, type-2 diabetes, and cardiovascular disease.
  Evolution of Influenza Viruses - prediction of possible future antigenic variants
  Prof D Smith
Application Deadline: 2 January 2020

Funding Type

PhD Type

Evolution of Influenza Viruses. Centre for Pathogen Evolution. Department of Zoology. University of Cambridge. Project summary. Our research focus is to design and develop analytical, computational, and mathematical methods to understand the fundamental processes that govern the evolution of influenza viruses.
  MRC DTP 4 Year PhD Programme: Molecular simulation study of the Nrf2-Keap1 pathway, the master regulator of cellular redox homeostasis
  Dr A Pisliakov, Prof A Dinkova-Kostova
Application Deadline: 11 January 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Using genotype-to-phenotype analyses to identify the genetic determinants of gastroenteritis caused by the food-borne pathogen Campylobacter jejuni
  Dr C D Bayliss, Prof J Ketley
Application Deadline: 12 January 2020

Funding Type

PhD Type

Campylobacter jejuni is the major causative agent of foodborne gastroenteritis across Europe. Contaminated chicken meat is the main source of infections and hence control of this pathogen is critical to food security in the poultry industry.
  *EASTBIO* Modelling telomere length dynamics in a multicellular organism.
  Research Group: Biomedical Sciences Research Centre
  Dr H Ferreira
Application Deadline: 5 January 2020

Funding Type

PhD Type

BBSRC Thematic Group. Health. Telomeres are protective structures that cap the ends of linear chromosomes. At their core, telomeres are formed from hundreds to thousands of repeats of a consensus telomeric DNA sequence.
  Understanding bone mass using collageneases and aggrecanases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

Bone is not only essential for locomotion, support and protection but crucial for many aspects of animal and human health. Specifically, bone is a calcium/phosphorous reservoir, is integral to glucose metabolism, houses the hematopoietic system and cross-talks with renal and reproductive systems.
  QUADRAT DTP: Actions of early life endocrine-disrupting chemical exposure on adult fish health using the zebrafish model
  Prof S Martin, Prof G Hardiman
Application Deadline: 22 January 2020

Funding Type

PhD Type

Landfills and other legacy waste sites in coastal zones are major sources of persistent organic pollutants (POPs), including polychlorinated biphenyl (PCBs), Perfluoroalkyl substances (PFASs) and polybrominated diphenyl ethers (PBDEs), to transitional waters and marine environments.
  Statistical genetics and genomics of complex traits
  Dr L Leach, Prof Z Luo
Applications accepted all year round

Funding Type

PhD Type

A highly motivated student is sought to train as a statistical geneticist working on the dissection of complex trait phenotypes in human, plant and animal populations into their underlying genetic components.
  MRC DTP 4 Year PhD Programme: Metformin-associated B12 deficiency and cognitive function in Type 2 Diabetes
  Dr L Kang, Dr A Doney
Application Deadline: 11 January 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Dissection of host gene regulation during infection by an intracellular pathogen
  Dr L Morrison, Dr J Prendergast, Dr T Connelly
Application Deadline: 10 January 2020

Funding Type

PhD Type

How gene expression is regulated is key to determining how cells within an animal respond to infection. This is particularly important when cells are invaded by intracellular pathogens, and can determine infection, establishment and proliferation.
  EASTBIO Dark matter in the microbiome – assembling eukaryotic genomes from large metagenomic datasets
  Dr M Watson, Prof JN Newbold
Application Deadline: 5 January 2020

Funding Type

PhD Type

Royal (Dick) School of Veterinary Studies / The Roslin Institute.
  EASTBIO Dissecting the role of the immune system in tumour initiation using experimental & computational analysis
  Dr Y Feng, Dr L Schumacher
Application Deadline: 5 January 2020

Funding Type

PhD Type

The mechanisms that modulate the pre-neoplastic stage of tumourigenesis in vivo are largely unknown due to the lack of suitable animal models.
  EASTBIO The role and optimisation of the microbiome in molluscan larval development
  Dr T Bean, Dr FB Batista, Dr M Watson
Application Deadline: 5 January 2020

Funding Type

PhD Type

Royal (Dick) School of Veterinary Studies / The Roslin Institute. Bivalve hatcheries produce millions of juvenile animals for on-growing in aquaculture farms worldwide.
  Precision Medicine DTP - Analyzing network formation during brain tumour initiation
  Dr D Sieger, Prof P Uhlén
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. High grade brain tumours (HGBTs) represent a complex and devastating disease and are posing an unmet clinical need. These tumours resist multi-modal therapies and survival times are only 15 months on average.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Molecular mechanisms of influenza virus replication
  Prof E Fodor
Application Deadline: 10 January 2020

Funding Type

PhD Type

Influenza viruses are important human and animal pathogens; they cause widespread clinical and veterinary disease and have a considerable economic impact.
  *EASTBIO* Impact of the microbiome on development and health
  Research Group: Biomedical Sciences Research Centre
  Dr I Somorjai
Application Deadline: 5 January 2020

Funding Type

PhD Type

BBSRC Thematic Group. Frontier Bioscience. The gut microbiota - the complex community of bacteria, viruses and archaea with which we live - has an important impact on health, disease progression, lifespan and behaviour (Glendinning and Free 2014).
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