Bioinformatics (equality) PhD Projects, Programmes & Scholarships

(MRC DTP CASE) Determination of the role of viruses in the microbiome of biofilms formed in the ear of patients with otitis media

The University of Manchester Faculty of Biology, Medicine and Health

Otitis media (OM) is a very common infection of the middle ear characterised by redness, swelling and build-up of fluid behind the eardrum. Read more

Supervisors: Prof P Vallely, Prof P Klapper, Prof S Lovell, Mrs JN Nichani

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Eco-evolutionary dynamics of environmental microbiomes

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Prof M Brockhurst, Dr S Nixon, Dr K Coyte

15 June 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health

Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more

Supervisors: Dr J Ellingford, Prof R O'Keefe

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry

Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more

Supervisor: Prof S Hay

27 October 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health

Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development and validation of a radiosensitivity gene expression signature in prostate cancer

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is diagnosed in 1.4 million men globally each year and causes 375,000 deaths, making PCa the second most common cancer and fifth most common cause of death from cancer in men[1]. Read more

Supervisors: Prof A Choudhury, Dr MR Reardon, Dr TS Smith

Year round applications PhD Research Project Self-Funded PhD Students Only

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Modelling the ecology and evolution of microbial communities

The University of Manchester Faculty of Biology, Medicine and Health

From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more

Supervisors: Dr K Coyte, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the genetic basis of immunological overlap between inflammatory diseases

The University of Manchester Faculty of Biology, Medicine and Health

Genetic studies have identified numerous variants within the human genome associated with susceptibility to common complex inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). Read more

Supervisors: Mr P Martin, Prof S Eyre, Prof A Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

The University of Manchester Faculty of Biology, Medicine and Health

Rare diseases affect. This proposal builds on substantial efforts of a Human Genome Organization committee which has proposed a unified professional-standard for representing genomic data which, when finalised, will be adopted world-wide. Read more

Supervisors: Dr S Pettifer, Dr PF Freeman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using Exposome, Omics, and AI to Develop a Digital Platform for Tailoring the Care of Children with Autism Spectrum Disorders

University of Bradford Faculty of Life Sciences

Autism spectrum disorders (ASD) are characterized by social impairments, repetitive behaviours, and restricted interests [1]. Over the past 20 years, there is a significant increase in the incidence of Autism spectrum disorders in the UK [1]. Read more

Supervisors: Dr S Morsy, Dr M Elshehaly, Prof C Wright

22 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Molecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

The heart’s pacemaker, the sinus node, initiates the action potential that causes the heart to beat, and the atrioventricular node conducts the action potential from the atria to the ventricles, the pumping chambers of the heart. Read more

Supervisors: Dr M Hussain, Dr C Willis, Prof MR Boyett

Year round applications PhD Research Project Self-Funded PhD Students Only

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Self funded MSc by research or PhD in Biology: Investigating chromosome segregation in thermophilic Archaea

University of York Department of Biology

Lead supervisor: Prof D Barilla. Co-Supervisor: Prof G Thomas. The student will be registered with the Department of Biology. Read more

Supervisor: Prof D Barilla

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Self funded MSc by research or PhD in Biology: Discovery, evolution and applications in plant natural product biosynthesis

University of York Department of Biology

Lead supervisor: . The student will be registered with the Department of Biology. Plants are capable of producing complex molecules for defense and adaptation. Read more

Supervisor: Dr B R Lichman

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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New methods for modelling radionuclide binding proteins

The University of Manchester Department of Chemistry

The management of radioactively contaminated land and water is a multi-billion pound, 100+ year grand challenge that requires innovation to minimise costs. Read more

Supervisors: Prof S Hay, Dr L Natrajan

Year round applications PhD Research Project Competition Funded PhD Project (UK Students Only)

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Self funded MSc by Research or PhD in Biology: The oncogenic mechanism and potential of the emergent retrovirus ALV-K in global poultry

University of York Department of Biology

Lead supervisor: Dr Andrew Mason. The student will be registered with the Department of Biology. Background. Avian Leukosis Viruses (ALV) are oncogenic retroviruses which cause blood cancers in chickens, impacting commercial productivity and animal welfare. Read more

Supervisor: Dr A Mason

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Self funded MSc by research or PhD in Biology: Chemical warfare in the rhizosphere: understanding the defensive role of plant root exudates against the bacterial pathogen Ralstonia solanacearum

University of York Department of Biology

Lead supervisor. Dr Andrea Harper. The student will be registered with the Department of Biology. R. solanacearum is a devastating bacterial plant pathogen that has a global distribution, wide host range, and no effective control methods. Read more

Supervisor: Dr A Harper

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Investigation of crystal formation in pharmaceutical crystallisation processes

University of Strathclyde Department of Chemical and Process Engineering

Formation of crystals is a crucial part of many manufacturing processes in industries including pharmaceuticals, foods, chemicals and advanced materials. Read more

Supervisors: Prof J Sefcik, Dr M Haw

Year round applications PhD Research Project Self-Funded PhD Students Only

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Interpretable machine learning to identify biomarkers from multi-omics data of human cancer

The University of Manchester Department of Computer Science

This project aims to address the critical field of cancer research, a leading cause of death globally. Read more

Supervisor: Dr H Zhou

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Data-driven optimal prediction of bacteria growth

The University of Manchester Department of Mechanical, Aerospace and Civil Engineering

This project is devoted to an AI-based prediction of bacteria growth and its control by antibiotics. In synthetic biology, an improved understanding of bacterial regulatory circuits is required to develop complex biological systems with functionalities beyond existing in nature [1, 2]. Read more

Supervisor: Dr S Utyuzhnikov

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterising human sebum using NMR approaches

The University of Manchester Department of Chemistry

We have recently shown that skin secretions in particular sebum, has a critical diagnostic role in other diseases unrelated directly to the skin. Read more

Supervisors: Dr D K Trivedi, Prof M Nilsson, Prof GA Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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NMR approaches for understanding mass transfer in microbial biofilms and sessile microbial communities

The University of Manchester Department of Chemistry

Biofilms are structured sessile communities of microorganisms with relevance in many areas of life. They are almost omnipresent in aquatic and terrestrial ecosystems. Read more

Supervisors: Prof M Nilsson, Prof A McBain

Year round applications PhD Research Project Self-Funded PhD Students Only

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Where has all of the carbon gone? Understanding the molecular mechanisms of long-term soil carbon capture

The University of Manchester Department of Earth and Environmental Sciences

Soils, while unglamorous, form the basis of the terrestrial biosphere and are ultimately the source of the majority of the food that we eat, yet fundamental aspects of how soils form and how they store carbon are poorly understood. Read more

Supervisors: Prof D Cameron, Dr S Nixon

Year round applications PhD Research Project Funded PhD Project (UK Students Only)

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NIHR GOSH BRC Translational Research (Non-Clinical) PhD Studentships

Great Ormond Street Hospital for Children NHS Trust

The NIHR Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC) PhD Studentship Programme aims to fund five highly motivated non-clinical PhDs students to support the training and development of the next generation of translational researchers. Read more

Funded PhD Programme (UK Students Only) PhD Opportunities

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Novel glycoprotease discovery and characterisation for enhanced detergent performance

Newcastle University BiSCoP CTP

In this exciting joint academia-industry project the student will exploit metagenomes and the huge untapped capacity of the human gut microbiota to breakdown glycoconjugates to discover novel protease enzymes that can potentially increase the performance and environmental sustainability of leading P&G automatic dishwashing brands. Read more

Supervisors: Dr E Lowe, Dr D Bolam, Dr AL Morales Garcia, Mrs K Bell-Rusiewicz

2 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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We have 30 Bioinformatics (equality) PhD Projects, Programmes & Scholarships

Bioinformatics (equality) PhD Projects, Programmes & Scholarships

We have 30 Bioinformatics (equality) PhD Projects, Programmes & Scholarships

(MRC DTP CASE) Determination of the role of viruses in the microbiome of biofilms formed in the ear of patients with otitis media

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

Eco-evolutionary dynamics of environmental microbiomes

Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

New Methods for modelling cofactor-dependent enzyme structure and function

Discerning the role of metabolic proteins in nucleus

Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

Development and validation of a radiosensitivity gene expression signature in prostate cancer

Modelling the ecology and evolution of microbial communities

Investigating the genetic basis of immunological overlap between inflammatory diseases

A deep-learning approach to genomic regulation of tissue-specific alternative splicing

Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

Understanding how to target the T cell compartment within related brain tumours

VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

Using Exposome, Omics, and AI to Develop a Digital Platform for Tailoring the Care of Children with Autism Spectrum Disorders

Molecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes

Self funded MSc by research or PhD in Biology: Investigating chromosome segregation in thermophilic Archaea

Self funded MSc by research or PhD in Biology: Discovery, evolution and applications in plant natural product biosynthesis

New methods for modelling radionuclide binding proteins

Self funded MSc by Research or PhD in Biology: The oncogenic mechanism and potential of the emergent retrovirus ALV-K in global poultry

Self funded MSc by research or PhD in Biology: Chemical warfare in the rhizosphere: understanding the defensive role of plant root exudates against the bacterial pathogen Ralstonia solanacearum

Investigation of crystal formation in pharmaceutical crystallisation processes

Interpretable machine learning to identify biomarkers from multi-omics data of human cancer

Data-driven optimal prediction of bacteria growth

Characterising human sebum using NMR approaches

NMR approaches for understanding mass transfer in microbial biofilms and sessile microbial communities

Where has all of the carbon gone? Understanding the molecular mechanisms of long-term soil carbon capture

NIHR GOSH BRC Translational Research (Non-Clinical) PhD Studentships

Novel glycoprotease discovery and characterisation for enhanced detergent performance

We have 30 Bioinformatics (equality) PhD Projects, Programmes & Scholarships

Bioinformatics (equality) PhD Projects, Programmes & Scholarships

We have 30 Bioinformatics (equality) PhD Projects, Programmes & Scholarships

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