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University of Birmingham Bioinformatics PhD Projects, Programs & Scholarships

We have 22 University of Birmingham Bioinformatics PhD Projects, Programs & Scholarships

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Showing 1 to 22 of 22
  Deriving a new weighted capitation model for UK General Practice
  Prof T Marshall
Applications accepted all year round

Funding Type

PhD Type

BACKGROUND. Capitation payments make up the majority of General Practice income in the UK NHS. Capitation payments are weighted using the Carr-Hill formula to take account of factors affecting workload.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  The Role of LIM Domain Only Proteins in Neuroblastoma
  Dr M Hoogenkamp
Applications accepted all year round

Funding Type

PhD Type

Person Specification. An Upper Second Class Honours Degree (or equivalent) in a relevant study or Master’s degree is expected. Prior experience in cell and molecular biology is an advantage.
  Development of novel artificial intelligence algorithms for network wide metabolic flux analysis with stable isotope tracers
  Dr C Ludwig, Dr S He
Applications accepted all year round

Funding Type

PhD Type

The efficient function of the metabolic network in eukaryotic cells relies on its separation into a number of closely-linked but metabolically distinct compartments.
  Identification of novel regulators of pancreatic beta-cell identity
  Dr I Akerman
Application Deadline: 31 October 2019

Funding Type

PhD Type

Diabetes is the largest epidemic in human history that affects 1 in 12 adults worldwide. Due to our modern lifestyle, it is one of the few diseases where the incidence is set to rise dramatically, with projections putting 650 million people at risk by 2040.
  Targeting steroid metabolism to block colorectal cancer proliferation
  Dr P Foster, Dr L Cox
Applications accepted all year round

Funding Type

PhD Type

Our group is a world leader in targeting specific aspects of steroid metabolism to block cancer growth. Our research has been instrumental in the successful pre-clinical and clinical development of various novel anti-cancer compounds.
  Vitamin D and immunometabolism
  Prof M Hewison, Dr S Dimeloe
Applications accepted all year round

Funding Type

PhD Type

Vitamin D has potent anti-inflammatory and antibacterial immune effects.
  Elucidating the emergence of multi-drug resistant Enterococcus faecium
  Prof W Van Schaik, Dr A McNally
Applications accepted all year round

Funding Type

PhD Type

The Gram-positive bacterium Enterococcus faecium is a commensal of the intestinal tract of humans and animals. However, over the last two decades a clone of E.
  Evolution of multi-drug resistant gram negative clones
  Dr A McNally, Prof W Van Schaik
Applications accepted all year round

Funding Type

PhD Type

Increasing antibiotic resistance in bacterial infections is a serious threat to modern medicine, so understanding why some bacteria become resistant to multiple antibiotics whereas others do not is an important challenge for microbiologists, doctors and vets.
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  Understanding and combatting antimicrobial resistance plasmids
  Dr M Buckner, Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is a major crisis for human medicine. Globally, untreatable bacterial infections are rapidly increasing, leaving us with limited treatment options.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Applications accepted all year round

Funding Type

PhD Type

ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
  Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
  Dr M Soller, Prof F Mueller
Applications accepted all year round

Funding Type

PhD Type

Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017).
  Eukaryotic gene expression: understanding the role of UPF1 in global mRNA processing and amyotrophic lateral sclerosis (ALS)
  Dr S Brogna
Applications accepted all year round

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Integrating metabolomics, imaging and bioinformatics to develop physiology-based kinetic models for chemical safety science
  Prof M Viant, Dr B Campos, Dr C Rivetti, Dr I Sorrell
Application Deadline: 22 September 2019

Funding Type

PhD Type

**If you are interested in this studentship, it is vital to contact Professor Mark Viant prior to application with a copy of your CV.
  Investigating the influence of polyploidy on the evolution of a major human fungal pathogen
  Dr E Ballou
Applications accepted all year round

Funding Type

PhD Type

The human fungal pathogen Cryptococcus neoformans undergoes an unusual morphological transition from haploid yeast to highly polyploid Titan cells during infection of the human host.
  Methods for quantitative genetic analyses in autotetraploids
  Prof Z Luo
Applications accepted all year round

Funding Type

PhD Type

Methods for quantitative genetic analysis have been well established in almost all important diploid plants and animal including humans, and have served as essential tools for dissecting the genetic architectures underlying agronomically, evolutionarily and medically interesting quantitative and complex traits.
  mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr PG Grzechnik
Applications accepted all year round

Funding Type

PhD Type

For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  Statistical genetics and genomics of complex traits
  Dr L Leach, Prof Z Luo
Applications accepted all year round

Funding Type

PhD Type

A highly motivated student is sought to train as a statistical geneticist working on the dissection of complex trait phenotypes in human, plant and animal populations into their underlying genetic components.
  Why do some DNA sequences poison cells?
  Research Group: BBSRC MIBTP
  Dr D Grainger
Applications accepted all year round

Funding Type

PhD Type

Life on our planet is permitted by an ancient set of instructions encoded by DNA. Consequently, the observation that a cell can be poisoned by its own DNA is completely counterintuitive.
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