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We have 9 Biological Sciences (polymerase) PhD Projects, Programmes & Scholarships

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Biological Sciences (polymerase) PhD Projects, Programmes & Scholarships

We have 9 Biological Sciences (polymerase) PhD Projects, Programmes & Scholarships

Understanding control of genome folding by cohesin

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Nuclear and transcriptional dysregulations during cellular senescence

Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more

Structural insights into genome control by cohesin

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Development of a DNA amplification-free assay for pathogen detection

Applications are invited for a funded PhD position in the School of Chemistry at the University of Birmingham. The School of Chemistry is keen to achieve a gender and diversity balance across the School and welcomes applicants from all backgrounds. Read more

Biosensor for Point-of-Care DNA Detection

DNA detection is needed for a range of applications including clinical diagnostics and environmental monitoring. As target DNA is often present in very low concentrations, it is typically amplified using methods such as polymerase chain reaction (PCR) [1], before detection. Read more

Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more
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