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We have 26 Biological Sciences (qub) PhD Projects, Programmes & Scholarships

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Biological Sciences (qub) PhD Projects, Programmes & Scholarships

We have 26 Biological Sciences (qub) PhD Projects, Programmes & Scholarships

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Selective targeting of furin for the treatment of fibrotic lung disease.

Queen’s University Belfast School of Pharmacy
Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more
 Supervisor: Prof L Martin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.

Queen’s University Belfast School of Pharmacy
Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more
 Supervisor: Prof L Martin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Breaking the resistance: alternative approaches to antibiotics discovery

Queen’s University Belfast School of Pharmacy
The World Health Organisation (WHO) identifies antimicrobial resistance (AMR) as one of the top 10 global threats to human health (http://www.who.int/). Read more
 Supervisor: Prof G Wagner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Microneedle delivery systems for minimally-invasive patient diagnosis/monitoring

Queen’s University Belfast School of Pharmacy
In this project, a novel type of integrated system will be investigated that will by-pass the skin barrier. On its surface will be multiple microscopic needles that pierce the skin without causing any pain – the sensation is said to feel like a cat’s tongue or sharkskin. Read more
 Supervisor: Prof R Donnelly
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Microneedle delivery systems for next-generation antibody therapeutics

Queen’s University Belfast School of Pharmacy
Microneedle arrays are minimally-invasive devices that painlessly, and without drawing blood, penetrate the skin’s stratum corneum barrier. Read more
 Supervisor: Prof R Donnelly
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of multifunctional biomaterials for urinary catheters to eradicate catheter-associated urinary tract infections

Queen’s University Belfast School of Pharmacy
Catheter-associated urinary tract infections (CAUTIs) are among the most common hospital-acquired infections worldwide threatening over 150 million people annually, imposing substantial burdens on the health system. Read more
 Supervisor: Dr SZ Zhang
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Designing and evaluating novel nanotherapeutics to enhance the effectiveness of radiotherapy in the treatment of solid cancers.

Queen’s University Belfast School of Pharmacy
One in two cancer patients will receive radiotherapy as part of their treatment. For patients with a localised cancer diagnosis effective radiotherapy represents the best chance of a curative outcome, however, is not without risk. Read more
 Supervisor: Dr J Coulter
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Synthetic Protein-Transporters for Enhanced Transduction Activity

Queen’s University Belfast School of Pharmacy
Intracellular protein delivery is key to probing important cellular processes and developing advanced biotherapeutics. However, protein trafficking into the cell, and more specifically to the cytosol remains a significant challenge. Read more
 Supervisor: Dr S Carmali
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Infection-responsive coatings for the prevention of catheter-associated urinary tract infections

Queen’s University Belfast School of Pharmacy
Medical care has transformed over the last century with significant improvements in the variety and extent to which various diseases can be treated and/or prevented. Read more
 Supervisors: Dr M Wylie, Prof C McCoy
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Biomaterial coatings with lubricious, slippery coatings for improved urinary catheter performance

Queen’s University Belfast School of Pharmacy
Intermittent urinary catheterisation is commonly used to address chronic urinary retention in patients suffering from conditions such as spinal cord injury, stroke, and multiple sclerosis. Read more
 Supervisors: Dr M Wylie, Prof C McCoy
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Designing next-generation urinary catheter materials for clean intermittent self-catheterisation through control of the urinary microbiome

Queen’s University Belfast School of Pharmacy
Intermittent urinary catheterisation is commonly used to address chronic urinary retention in patients suffering from conditions such as spinal cord injury, stroke, and multiple sclerosis. Read more
 Supervisors: Dr M Wylie, Dr L Sherrard
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of carbohydrate-functionalised materials for detection and prevention of medical device-associated infections

Queen’s University Belfast School of Pharmacy
Antibiotic-resistant bacteria are a growing problem in the 21st century, causing longer and more serious infections, and resulting in poor outcomes for vulnerable patients. . Read more
 Supervisor: Dr M Wylie
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Does one size fit all for antimicrobial delivery via nanoparticles

Queen’s University Belfast School of Pharmacy
Antimicrobial resistant bacteria are a growing problem and new ways are needed to target bacterial infections more efficiently. One way in which bacteria can avoid therapeutics is via intracellular infection, where they hide within our own cells. Read more
 Supervisors: Dr J Burrows, Prof B Gilmore
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Regulation of CaaX protein processing

Queen’s University Belfast School of Pharmacy
USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types, as well as the migration of a range of cancer cells (NSCLC, breast, ovarian, osteosarcoma).    . Read more
 Supervisor: Dr J Burrows
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of carers in medicines management for people living with dementia

Queen’s University Belfast School of Pharmacy
It is estimated that there are close to 50 million people living with dementia worldwide, and this number is estimated to double every 20 years. Read more
 Supervisors: Dr H Barry, Prof C Hughes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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