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We have 120 The University of Manchester Biological Sciences PhD Projects, Programmes & Scholarships

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The University of Manchester Biological Sciences PhD Projects, Programmes & Scholarships

We have 120 The University of Manchester Biological Sciences PhD Projects, Programmes & Scholarships

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Blocking proteins as a novel approach to treat blood cancer

The University of Manchester Cancer Research UK Manchester Institute
4 Year PhD Studentship - Autumn 2024. Cancer Research UK Manchester Institute. Project Title. "Blocking proteins as a novel approach to treat blood cancer". Read more
 Supervisor: Prof T Somervaille
 17 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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(MRC DTP CASE) Development of new in vitro infection models to tackle antimicrobial resistance

The University of Manchester Faculty of Biology, Medicine and Health
Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. Read more
 Supervisors: Dr S Gago, Dr M Bertuzzi, Dr J Bella
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Neurovascular coupling in cerebral hypoperfusion

The University of Manchester Faculty of Biology, Medicine and Health
There are almost a million people living with dementia in the UK. Most of these cases comprise Alzheimer’s Disease (AD), vascular dementia (VaD) or, as is increasingly recognised, a mixed picture phenotype with evidence of the two conditions co-existent in the same patient. Read more
 Supervisors: Dr H Pritchard, Dr A Greenstein, Dr I Schiessl, Prof S Allan
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Investigating the effect of plastics recycling on nanoplastic production in packaging applications

The University of Manchester Department of Materials
Nanoplastics, defined as plastic particles measuring less than 1000 nanometres, have emerged as a significant concern due to their ability to infiltrate ecosystems, posing potential risks to the environment. Read more
 Supervisor: Dr T McDonald
 25 August 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data.

The University of Manchester Department of Computer Science
Rare diseases affect <1-in-2,000 people, but ~8,000 rare genetic diseases impact ~10% of births globally. These arise from variations in patients’ DNA sequences. Read more
 Supervisors: Dr S Pettifer, Dr PF Freeman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(BRC) Nailfold capillary imaging in the idiopathic inflammatory myopathies (Non-Clinical)

The University of Manchester Faculty of Biology, Medicine and Health
The idiopathic inflammatory myopathies (IIMs) are rare conditions characterised by distinct clinical subtypes and varied multisystem involvement. Read more
 Supervisors: Dr A Murray, Dr H Chinoy, Dr J Lamb
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) A prototype smart disposable device for ophthalmic point-of-care

The University of Manchester Faculty of Biology, Medicine and Health
This project seeks to design and develop a small device which will fit comfortably behind the lower eyelid in order to soak up a small volume of tears such that the biomarkers contained in tears – including some of the thousands or proteins in the human tear film – can be easily removed and analysed. Read more
 Supervisors: Prof P Morgan, Prof J Gough
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Determination of the role of viruses in the microbiome of biofilms formed in the ear of patients with otitis media

The University of Manchester Faculty of Biology, Medicine and Health
Otitis media (OM) is a very common infection of the middle ear characterised by redness, swelling and build-up of fluid behind the eardrum. Read more
 Supervisors: Prof P Vallely, Prof P Klapper, Prof S Lovell, Mrs JN Nichani
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health
Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more
 Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) The emerging fungal order Mucorales: species-specific pathogenic strategies and new diagnostics

The University of Manchester Faculty of Biology, Medicine and Health
Mucormycoses are emerging lethal fungal infections, with striking mortality rates of 50-90% depending on the clinical presentation, infection site and underlying host immune status. Read more
 Supervisors: Dr M Bertuzzi, Dr N.V.R Van Rhijn
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Investigating the mechanisms contributing to impaired regulatory function of B cells in autoimmunity

The University of Manchester Faculty of Biology, Medicine and Health
The implementation of biological therapies has significantly advanced the management of autoimmune diseases (AIDs). However, the failure to achieve clinical remission in ‘non-responders’ remains a significant and unmet challenge. Read more
 Supervisors: Dr MM Mennon, Prof MH Buch
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Understanding Disease Management and Outcomes for Myositis Patients: An International Real-World Study Utilising Multiple Data Sources to Investigate Treatment Patterns, Health-Related Quality of Life, Clinical Outcomes, and Burden of Illness for Patients With Rare Autoimmune Disease

The University of Manchester Faculty of Biology, Medicine and Health
Myositis is a group of rare conditions which present with physical symptoms that can significantly impact a patient’s life. Many patients are permanently disabled due to irreversible muscle damage. Read more
 Supervisors: Dr H Chinoy, Dr AO Oldroyd
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

The University of Manchester Faculty of Biology, Medicine and Health
Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more
 Supervisors: Prof D Brough, Dr K Couper
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health
Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more
 Supervisors: Dr A Politis, Dr CP Pliotas
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Designing Peptide hydrogels as vehicles for targeted and localised in-vivo therapeutics delivery

The University of Manchester Faculty of Biology, Medicine and Health
One of the key engineering challenges in the life-science and biomedical sectors is the design and manufacturing of bespoke hydrogels for 3D cell culture, tissue engineering and cell/drug delivery. Read more
 Supervisors: Prof A Saiani, Dr K Finegan
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Mapping CD4+ T cell fate decisions and functional coordination within tissues during infection

The University of Manchester Faculty of Biology, Medicine and Health
CD4+ T cells are essential components of the immune system, orchestrating protection against infection. Read more
 Supervisors: Dr K Couper, Prof DD Dyer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health
T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more
 Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Developing novel Electron Paramagnetic Resonance Methods for Pulsed Dipolar Spectroscopy and Quantum Information Processing

The University of Manchester Department of Chemistry
In the last decade significant improvements in the hardware available for Electron Paramagnetic Resonance measurements. Read more
 Supervisors: Dr A Bowen, Prof E McInnes, Prof D Collison, Prof R Winpenny
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Developing novel light-induced in-situ Electron Paramagnetic Resonance (EPR) methods

The University of Manchester Department of Chemistry
Light-induced in-situ Electron Paramagnetic Resonance (EPR) studies are a growing field in both continuous wave and pulsed EPR. It can be used to monitor photoactivated chemical and biochemical reactions involving radical reagents, projects or intermediates. Read more
 Supervisors: Dr A Bowen, Prof D Collison, Dr A Golovanov
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry
A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more
 Supervisor: Prof A Green
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Building Enzymes with New Catalytic Functions & Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry
A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more
 Supervisor: Prof A Green
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

The University of Manchester Faculty of Biology, Medicine and Health
Rare diseases affect. This proposal builds on substantial efforts of a Human Genome Organization committee which has proposed a unified professional-standard for representing genomic data which, when finalised, will be adopted world-wide. Read more
 Supervisors: Dr S Pettifer, Dr PF Freeman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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New methods for modelling radionuclide binding proteins

The University of Manchester Department of Chemistry
The management of radioactively contaminated land and water is a multi-billion pound, 100+ year grand challenge that requires innovation to minimise costs. Read more
 Supervisors: Prof S Hay, Dr L Natrajan
 Year round applications  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

The University of Manchester Department of Chemistry
Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more
 Supervisors: Dr S Lovelock, Dr C Markin
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health
RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more
 Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health
The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more
 Supervisors: Dr M Lagator, Prof M Rattray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Geomicrobiological controls on radionuclide speciation and fate during the geodisposal of radioactive waste

The University of Manchester Department of Earth and Environmental Sciences
Context. The UK has been generating electricity from nuclear power for over sixty years. Consequently, the safe disposal of the UK’s existing ~750,000 m3 of radioactive waste is a clear priority. Read more
 Supervisors: Prof J Lloyd, Prof S Shaw, Dr A Uknnl
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Machine learning for early and personalised risk assessment for pathological myopia

The University of Manchester Department of Mechanical, Aerospace and Civil Engineering
This project aims to assess if vascular analysis in retinal images can be used for personalised and early myopic degeneration/pathological myopia risk prediction. Read more
 Supervisors: Dr A Harish, Dr H Radbakrishnan, Dr A Revell
 31 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Delineating the IRF6 regulatory network driving periderm formation and function

The University of Manchester Faculty of Biology, Medicine and Health
During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more
 Supervisors: Prof M Dixon, Dr J Dixon
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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