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University of Nottingham Biological & Medical Sciences PhD Projects, Programs & Scholarships

We have 31 University of Nottingham Biological & Medical Sciences PhD Projects, Programs & Scholarships

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Biological & Medical Sciences

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University of Nottingham

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We have 31 University of Nottingham Biological & Medical Sciences PhD Projects, Programs & Scholarships

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The development of Rab27 inhibitors for treatment of cancer cell invasion and proliferation

Rab27 small GTPases regulate movement and exocytosis of secretory granules in cell types including; melanocytes (melanosomes), T lymphocytes (lytic granules), granulocytes (azurophilic granules) and mast cells [1]. Read more

Conflict and Cooperation in Prokaryote Pangenomes

Prokaryotes mediate most of the biogeochemical cycles on the planet, are responsible for large numbers of diseases and are used in pharmaceutical and biotechnology industries to make new and interesting compounds. Read more

What really makes a bacterial lipoprotein a real lipoprotein? Important implications for developing or improving lipoprotein-based vaccines

Bacterial lipoproteins have attracted much interest as vaccine candidates over recent years. The lipoprotein, Factor H binding protein, of Neisseria meningitidis for example is the sole antigen of Trumenba, the vaccine developed by Pfizer, and is a major component of the Bexsero vaccine developed by GSK. Read more

Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more

Sequence variation and epigenomic mechanisms underlying human neuropsychiatric and neurodegenerative diseases

This is the decade of the ‘brain’ and this is also the decade of advancements in ‘genomic technologies’. This project aims to use cutting edge sequencing technologies and molecular approaches to understand susceptibility to human disorders of the brain. Read more

Adjuvant therapies for mupirocin-resistant bacteria

Multi-drug resistant Staphylococcus aureus has been able to adapt constantly to therapeutic use of antibiotics and remains an important source of clinical complications, morbidity and mortality. Read more

Functional characterization of Neisserial toxin-antitoxin systems

Toxin-antitoxin (TA) systems are commonly found in both Gram-positive and Gram-negative bacteria and comprise a stable toxin able to stall bacterial replication and an antitoxin that neutralises the activity of the toxin. Read more

Defining the sequence requirements for neo-centromere function in the fission yeast Schizosaccharomyces pombe

Centromeres are the regions of the chromosome necessary for accurate segregation at cell division. They bind a complex set of proteins called the kinetochore which in turn tethers the chromosome to the microtubules of the spindle at cell division. Read more

Characterisation of novel inhibitors of vascular injury due to inflammation

Myeloperoxidase (MPO) is a haemoprotein that is highly expressed in neutrophils and is secreted during injury and inflammation to assist in host defence reactions by producing antimicrobial reactive oxygen species. Read more

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