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Biological Sciences (cell therapy) PhD Projects, Programmes & Scholarships

We have 64 Biological Sciences (cell therapy) PhD Projects, Programmes & Scholarships

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We have 64 Biological Sciences (cell therapy) PhD Projects, Programmes & Scholarships

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Project: Towards Engineered T Cells for Osteosarcoma

The aim of this project is to develop engineered T cells for osteosarcoma. Osteosarcoma is the most common bone cancer in adolescents and young adults (80% of the patients are younger than 25 years old) but nevertheless are rare cancer. Read more

A10 dopamine neurons: the missing link in cell therapeutics for Parkinson's disease?

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and degeneration of the nigral dopamine neurons is a key pathological feature of the condition. Read more

Identification of novel cortical interneuron regulators implicated in neuropsychiatric disorders

Despite representing only ~20% of the entire neuronal population in the neocortex, the GABAergic (Gamma-Aminobutyric Acid) inhibitory interneurons play a pivotal role in most cortical functions. Read more

Self funded BMS Project: Understanding the population dynamics of haematopoietic stem cells during gene therapy for sickle cell disease

Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more

Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy. Read more

Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting.

  Research Group: Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more

Advanced 3D models for Cancer Research

Radiotherapy and many chemotherapies kill cells by damaging DNA. The efficiency of these DNA damaging agents differs between tumour types and individual patients. Read more

Regulation of asymmetric cell division in brain cancer stem cells

Glioblastoma is the most lethal brain cancer in adults. Its poor prognosis is a result of aggressive tumour growth, therapeutic resistance, and tumour heterogeneity at the cellular and genetic level. Read more

Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

  Research Group: Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more

Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more

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