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Biological Sciences (metabolism) PhD Projects, Programmes & Scholarships

We have 98 Biological Sciences (metabolism) PhD Projects, Programmes & Scholarships

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We have 98 Biological Sciences (metabolism) PhD Projects, Programmes & Scholarships

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Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism

24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more

How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function

Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more

Mechanistic computational modelling of human glioblastoma metabolism

Glioblastoma is the most common and the most lethal malignant brain tumor. In vitro cell culture of glioma cells is essential for the discovery and development of novel anticancer treatments. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

How GABA neurones in the DVC control glucose metabolism

The Dorsal Vagal Complex (DVC) of the brain is an important regulator of glucose metabolism and food intake. The Nucleus of the Solitary Tract (NTS) in the DVC senses insulin and triggers a neuronal relay to decrease hepatic glucose production (HPG) in rodents. Read more

Cell/extracellular matrix interaction during cell cycle progression: a novel role in controlling nucleotide metabolism?

The deregulation of cell cycle progression is a common feature of cancer formation and progression. Cell/extracellular matrix (ECM) interaction is widely known to support the progression of the cells through the cell cycle. Read more

Engineering more water-use efficient crops: functional genomics of CO2 fixation during Crassulacean acid metabolism

The world is getting hotter and drier due to climate change, and the human population is growing rapidly to the extent that it has been predicted that we will need to increase crop yields by 50 - 70 % by 2050 in order to feed the predicted 9 - 10 billion people. Read more

Influence of exercise and/or nutrition on bone and cartilage metabolism

Loughborough University is a top-ten rated university in England for research intensity (REF, 2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%. Read more

Polmorphisms in cytosolic drug metabolising enzymes: a combined proteomics and modelling approach to clinical impact

Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs). Read more

Determining brain glycosylation in ageing and Alzheimer’s disease

  Research Group: Pharmacology and Experimental Therapeutics
Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism. Read more

Validation of TRAF6/PD-L1 inhibition in pre-clinical models of multiple myeloma: implications for combinational immunotherapy

Programmed death-ligand 1(PD-L1), a negative regulator of the immune system, is highly expressed in newly-diagnosed and relapsed multiple myeloma patients, and its expression is associated with suppressed anti-tumour immunity. Read more

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