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Biological Sciences (metabolism) PhD Projects, Programmes & Scholarships
We have 98 Biological Sciences (metabolism) PhD Projects, Programmes & Scholarships
We have 98 Biological Sciences (metabolism) PhD Projects, Programmes & Scholarships
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Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism
24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more
How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Macrophage-driven lipid metabolism in health and disease
Type of project. PhD Research Project. Funded PhD project (students worldwide). Applications accepted up to 30 August 2022. Supervisor. Read more
Mechanistic computational modelling of human glioblastoma metabolism
Glioblastoma is the most common and the most lethal malignant brain tumor. In vitro cell culture of glioma cells is essential for the discovery and development of novel anticancer treatments. Read more
A role for cholesterol metabolism in neurodevelopmental disorder
Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more
Identification of novel combination therapies exploiting nucleotide metabolism and DNA repair to treat cancer
Nucleotide analogues (antimetabolites) are used as anti-cancer treatments in the clinic for many decades, most commonly for the treatment of haematological, breast, ovarian and intestinal cancers. Read more
How GABA neurones in the DVC control glucose metabolism
The Dorsal Vagal Complex (DVC) of the brain is an important regulator of glucose metabolism and food intake. The Nucleus of the Solitary Tract (NTS) in the DVC senses insulin and triggers a neuronal relay to decrease hepatic glucose production (HPG) in rodents. Read more
Understanding metabolism in the blood cancer multiple myeloma and its precursor condition MGUS
Applications will be reviewed until a suitable candidate is appointed and funding is available. Read more
Cell/extracellular matrix interaction during cell cycle progression: a novel role in controlling nucleotide metabolism?
The deregulation of cell cycle progression is a common feature of cancer formation and progression. Cell/extracellular matrix (ECM) interaction is widely known to support the progression of the cells through the cell cycle. Read more
Engineering more water-use efficient crops: functional genomics of CO2 fixation during Crassulacean acid metabolism
The world is getting hotter and drier due to climate change, and the human population is growing rapidly to the extent that it has been predicted that we will need to increase crop yields by 50 - 70 % by 2050 in order to feed the predicted 9 - 10 billion people. Read more
Influence of exercise and/or nutrition on bone and cartilage metabolism
Loughborough University is a top-ten rated university in England for research intensity (REF, 2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%. Read more
Polmorphisms in cytosolic drug metabolising enzymes: a combined proteomics and modelling approach to clinical impact
Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs). Read more
Determining brain glycosylation in ageing and Alzheimer’s disease
Research Group:
Pharmacology and Experimental Therapeutics
Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism. Read more
Preclinical validation of NUDT22 as target in lung cancer
We previously identified NUDT22 as an UDP-glucose hydrolase and an important new player in nucleotide and energy metabolism. Read more
Validation of TRAF6/PD-L1 inhibition in pre-clinical models of multiple myeloma: implications for combinational immunotherapy
Programmed death-ligand 1(PD-L1), a negative regulator of the immune system, is highly expressed in newly-diagnosed and relapsed multiple myeloma patients, and its expression is associated with suppressed anti-tumour immunity. Read more