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We have 18 University of Birmingham Biological Sciences PhD Projects, Programmes & Scholarships
University of Birmingham Biological Sciences PhD Projects, Programmes & Scholarships
We have 18 University of Birmingham Biological Sciences PhD Projects, Programmes & Scholarships
Decoding nucleosomal asymmetry – characterisation of asymmetric histone post-translational modifications and structural implications for nucleosomal engagement of reader complexes
Nucleosome position and dynamics profoundly modulate DNA transactions including transcription, replication and repair by controlling access to DNA of the molecular complexes that process genetic information. Read more
Integrative bioinformatics approaches for the identification of novel targets and therapeutics for cell cycle changes and cell death
We are looking for a PhD candidate with a passion to combine bioinformatics and computational biology, as well as next-generation sequencing and high-throughput 'omic technologies, to target cells and their development. Read more
Last chance to apply
Multi-omic characterisation of transcription initiation regulation in development and injury response
Early Stage Researcher. We are seeking an applicant for a fully funded HORIZON-MSCA-2023-DN PhD studentship/position in the Department of Cancer and Genomic Sciences at the University of Birmingham, in the group of Prof Ferenc Mueller. Read more
Functional evaluation of a genetic region associated with FP induced cardiovascular toxicity, heart rate and all-cause mortality
Application deadline - midday (GMT) Friday 10 January 2025. Additional supervisor. Professor Chris Denning, University of Nottingham. Read more
Inhibitor of DONSON-GINS interaction as an experimental tool and potential anticancer strategy
Application deadline - midday (GMT) Friday 10 January 2025. Inhibition of initiation of DNA replication is an attractive and promising anticancer strategy. Read more
A new level of gene regulation in tumour heterogeneity in colorectal cancer organoid models
Application deadline - midday (GMT) Friday 10 January 2025. Additional supervisor. Professor Dov Stekel, University of Nottingham. Read more
Epigenetic regulation of cell fate by non-canonical histone deacetylases
We are looking for a PhD candidate to study the role of non-canonical histone deacetylases in the regulation of cell fate. Read more
Reading, writing and molecular switching in the DNA-damage response
The proposed project revolves around a fascinating and unique class of regulatory proteins that seem to function as molecular shape-shifters, able to adopt a number of distinct structural forms each tailored to functionally specific downstream signalling processes. Read more
Studying how epigenetics controls DNA repair in neuronal cells
Background. Our DNA is under constant attack from a variety of DNA damaging agents, which pose a significant threat to development, neurological function, and organismal survival. Read more
Regulation of RNA:DNA hybrid metabolism for genome stability
Proper regulation of RNA:DNA hybrids such as misincorporated ribonucleotides and R-loops is important for genome stability and healthy development. Read more
Visualisation of the steps in the replisome assembly process.
Defects in the maintenance of genome integrity are the foremost drivers of cellular deterioration leading to neuropathology and cancer development in humans. Read more
Investigating the significance of PRMT1 methylation for chromatin biology
Arginine methylation is a post-translational modification that regulates many cellular processes including gene expression, genome stability… Read more
Investigating the radiobiology of protons and BNCT in head and neck tumour treatment
Background. Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide with an annual incidence of ~800,000 cases/year. Read more
Relevance of G2/M DNA synthesis for genome stability and RNA Pol II transcription
RNA Pol II transcription and DNA replication are the two essential processes that use the DNA in our cells as a substrate, allowing them to express the content of their genetic information and to propagate these instructions to daughter cells. Read more
Role of the RNA Pol II subunits in transcription regulation
The RNA Pol II complex is the RNA polymerase that transcribes the genes that codify for the proteins in our body. This complex allows expressing only the functional relevant parts of the genome for each specific cell type, generating all the cells in the organism from virtually the same DNA template. Read more
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