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Biological Sciences (cell therapy) PhD Projects, Programmes & Scholarships
We have 74 Biological Sciences (cell therapy) PhD Projects, Programmes & Scholarships
We have 74 Biological Sciences (cell therapy) PhD Projects, Programmes & Scholarships
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Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
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Gene correlation network showing differences in gene expression of effector T cells derived from the bone marrow or peripheral tissues affected by GVHD.
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
A10 dopamine neurons: the missing link in cell therapeutics for Parkinson's disease?
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and degeneration of the nigral dopamine neurons is a key pathological feature of the condition. Read more
Investigating Novel Cell Therapies for Biliary Atresia
Biliary atresia (BA) is a rare medical condition, occurring in small infants, in which the bile ducts outside and inside the liver become scarred and blocked. Read more
Identification of novel cortical interneuron regulators implicated in neuropsychiatric disorders
Despite representing only ~20% of the entire neuronal population in the neocortex, the GABAergic (Gamma-Aminobutyric Acid) inhibitory interneurons play a pivotal role in most cortical functions. Read more
4-year PhD Studentship: Apolipoprotein E-targeted stem cell gene therapy for people with Alzheimer’s disease
Alzheimer’s disease (AD) is a devastating progressive neurological disease, and a major increasing global health challenge. Read more
Self funded BMS Project: Understanding the population dynamics of haematopoietic stem cells during gene therapy for sickle cell disease
Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more
Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy
Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy. Read more
Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting.
Research Group:
Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more
Functional heterogeneity of FGF receptors in glioblastoma cancer stem cells
A 3 year fully funded PhD studentship is available in the Astroglia Cell Biology Group at Cardiff University’s European Cancer Stem Cell Research Institute. Read more
Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease. Read more
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TRANSCRIPTOMIC, PROTEOMIC AND BIOINFORMATICS ANALYSES OF CELL-BASED THERAPIES FOR CARTILAGE INJURIES IN HUMANS
Background. Versus Arthritis studentships are prestigious awards within the field of musculoskeletal research. This studentship gives the opportunity to join our Regenerative Medicine team at the RJAH orthopaedic hospital and Keele University. Read more
Regulation of asymmetric cell division in brain cancer stem cells
Glioblastoma is the most lethal brain cancer in adults. Its poor prognosis is a result of aggressive tumour growth, therapeutic resistance, and tumour heterogeneity at the cellular and genetic level. Read more
Molecular modelling and analysis of plasma cell cancers
Plasma cell neoplasms, including multiple myeloma, are cancers of the immune system that remain largely incurable despite major advances in therapy. Read more
Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy
Research Group:
Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more