University of Bradford Biological Sciences PhD Projects, Programmes & Scholarships

We have 39 University of Bradford Biological Sciences PhD Projects, Programmes & Scholarships

Novel strategy for treatment of chronic wounds via multi-functional liposomal nanocarriers

University of Bradford Faculty of Life Sciences

Research Group: Medicines Development and Pharmaceutical Sciences

A confounding issue of non-healing skin wounds is the presence of pathogenic bacteria, that protect themselves from conventional antibiotic treatments by encasing themselves within protective shields (biofilms). Read more

Supervisors: Dr X Liu, Prof R Falconer

Year round applications PhD Research Project Self-Funded PhD Students Only

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New Drugs for Brain Tumours: Prodrugs of Diazopropyne

University of Bradford Faculty of Life Sciences

Research Group: Medicines Development and Pharmaceutical Sciences

The propargyl group, introduced to temozolomide-like drugs for brain tumours by our colleagues in Nottingham, shows considerable pre-clinical promise and… Read more

Supervisors: Dr R Wheelhouse, Dr S Shnyder

Year round applications PhD Research Project Self-Funded PhD Students Only

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New Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics

University of Bradford Faculty of Life Sciences

Research Group: Medicines Development and Pharmaceutical Sciences

The imidazotetrazine ring system that forms the core of the anticancer drug temozolomide is a fascinating prodrug delivery device. Read more

Supervisors: Dr R Wheelhouse, Dr S Shnyder, Dr A Ramachandra Kurup Sasikala

Year round applications PhD Research Project Self-Funded PhD Students Only

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New Drugs for Brain Tumours: A Locoregional Implant Brain Tumours

University of Bradford Faculty of Life Sciences

Research Group: Medicines Development and Pharmaceutical Sciences

Next-generation temozolomide derivatives for the treatment of high-grade glioma have been developed at the University of Bradford. Read more

Supervisors: Dr R Wheelhouse, Prof A Paradkar, Dr S Shnyder

Year round applications PhD Research Project Self-Funded PhD Students Only

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Neuronal control of appetite: investigating the role of the extracellular matrix in controlling neuronal activity in the hypothalamus

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

Appetite regulation is complex, and its dysregulation has serious implications for health, being observed in multiple conditions e.g., obesity, anorexia, and type 2 diabetes. Read more

Supervisors: Dr SM Dickens, Dr G Helfer

Year round applications PhD Research Project Self-Funded PhD Students Only

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Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more

Supervisors: Dr P Drake, Dr S Shnyder

Year round applications PhD Research Project Self-Funded PhD Students Only

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Microbiology of Hip Arthroplasty Cements

University of Bradford Faculty of Life Sciences

Research Group: Centre for Skin Sciences

Replacement hip and knee arthroplasties are common surgeries, with 31,000 hip and 90,000 knee replacements performed in England in 2020-21. Read more

Supervisors: Dr A Scimone, Dr T Swift

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigation of the extracellular matrix as a regulator of Parkinson’s progression

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

Parkinson’s is the 2nd most common neurodegenerative disease, affecting around 1 in 20 people aged over 65. In the UK, the number of affected people is set to rise by 50% over the next 50 years due to ageing populations. Read more

Supervisor: Dr SM Dickens

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Supervisor: Dr H Sheldrake

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying cognitive and biochemical changes underlying lifestyle risk factors for dementia

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Dementia describes a group of age-associated conditions of which cognitive decline is a major feature. Alzheimer’s disease (AD) is the most common cause of dementia and is characterised by the onset of a gradual cognitive decline. Read more

Supervisors: Dr S McLean, Dr R Williamson

Year round applications PhD Research Project Self-Funded PhD Students Only

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How effective is 3D reconstructed human skin as an alternative to human skin for permeation studies?

University of Bradford Faculty of Life Sciences

The assessment of percutaneous absorption of molecules is a very important step in the evaluation of any transdermal drug delivery system. Read more

Supervisors: Dr X Liu, Dr M Isreb

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with EOC. Read more

Supervisors: Dr S Swaroop, Dr G Grimaldi, Dr ED Perkins

Year round applications PhD Research Project Self-Funded PhD Students Only

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Evaluating Photodynamic Therapy in colorectal cancer using patient-derived organoids

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Surgery is first line treatment and often in adjunct with chemotherapy. Read more

Supervisors: Dr MI Khot, Prof A Paradkar, Prof D Jayne

Year round applications PhD Research Project Self-Funded PhD Students Only

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ERK5 MAPK signalling in Alzheimer’s disease

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. Read more

Supervisors: Dr J Muller, Dr S Kantamneni

Year round applications PhD Research Project Self-Funded PhD Students Only

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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Supervisors: Dr S Shnyder, Dr S Kantamneni

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 39 University of Bradford Biological Sciences PhD Projects, Programmes & Scholarships

University of Bradford Biological Sciences PhD Projects, Programmes & Scholarships

We have 39 University of Bradford Biological Sciences PhD Projects, Programmes & Scholarships

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