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Biophysics (antibiotic) PhD Projects, Programs & Scholarships

We have 19 Biophysics (antibiotic) PhD Projects, Programs & Scholarships

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We have 19 Biophysics (antibiotic) PhD Projects, Programs & Scholarships

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Simulation-led investigation and engineering of enzymes involved in abyssomicin antibiotic biosynthesis

Enzymes are remarkable biocatalysts that allow rapid, selective and efficient catalysis under mild conditions. Biotechnology exploits the outstanding rate-enhancing properties of these natural biocatalysts to manufacture high added-value products. Read more

High-throughput discovery of novel antibiotics using synthetic microbiology

Antimicrobial resistance (AMR) is a frequent problem in the treatment of disease caused by several clinical bacterial pathogens. In the European Union, antibiotic-resistant infections kill nearly 25,000 patients and represent a total expenditure of £1.5 billion per year. Read more

EASTBIO High throughput real time imaging of bacterial cells exposed to antibiotics

  Research Group: Institute of Cell Biology
Our society is currently facing an important problem with the rise of multiple antibiotic resistant bacterial strains. As the development of new antibiotics has stalled in recent years, new strategies are urgently needed to supplement current available therapies. Read more

Adjuvant therapies for mupirocin-resistant bacteria

Multi-drug resistant Staphylococcus aureus has been able to adapt constantly to therapeutic use of antibiotics and remains an important source of clinical complications, morbidity and mortality. Read more

(BBSRC DTP) Single-cell measurements of mutation dynamics across bacterial DNA

Genetic mutations are the raw material of evolution, driving evolutionary innovations. Mutation rate is thus a key factor determining how organisms adapt to new environments and whether they survive a severe environmental challenge, such as antibiotic treatment in the case of bacteria. Read more

Biofilms - From Structure-Function to Antimicrobial Discovery

Antibiotic resistance has emerged as a major threat to public health. The treatment of many clinically relevant pathogenic bacteria pathogen has become increasingly difficult due to their capacity to resist antibiotics. Read more

White Rose BBSRC DTP studentship: Understanding the dynamics of non-ribosomal peptide synthetases

Non-ribosomal peptide synthetases are dynamic molecular machines which produce some of the most important medicinal compounds including the antibiotic vancomycin, the immunosuppressant rapamycin and the anticancer agent Bleomycin. Read more

Understanding and control of electric communication in bacteria colonies, using machine learning

Although initial discussions regarding bioelectricity and its role in the fundamental understanding of various cellular behaviours took place in the 1970s, the bioelectrical view of cells as a more general concept has remained limited to the fringes of biological research for five decades. Read more

Understanding bacterial DNA gyrase for the development of novel antibiotics

  Research Group: Physics of Life - Biological Physics and Biophysics
DNA gyrase is an enzyme found in all bacteria that can, uniquely, introduce supercoils into DNA. Its topoisomerase reaction involves the generation of transient double-stranded breaks in DNA. Read more

Cascading failure of the aorta - The role of collagen degradation in the development of aortic dissection

The aorta is the largest conduit for blood flow in the human body and vital for cardiovascular health. Aortic dissection (AD) occurs when there is a split in the wall of the aorta, resulting in the creation of an artificial channel for blood flow, which can lead to rupture. Read more

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