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Biophysics (transcription) PhD Projects, Programs & Scholarships

We have 22 Biophysics (transcription) PhD Projects, Programs & Scholarships

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  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  (BBSRC DTP) Development of anti-cancer agents and biomarkers that target intrinsically disordered regions of transcription factors and protein kinases
  Prof J Waltho, Dr A Almond
Application Deadline: 31 January 2020

Funding Type

PhD Type

The controlled manipulation of transcription factors, protein kinases and protein phosphatases is central to improving our understanding of cellular processes and, importantly, in the development of next-generation therapeutics for a variety of cancers.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round

Funding Type

PhD Type

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Replication and transcription machinery collisions in Escherichia coli.
  Dr M Hawkins, Prof M Leake
Application Deadline: 5 January 2020

Funding Type

PhD Type

DNA duplication is essential for life but replication forks can be blocked when. they collide with proteins bound to DNA. Exactly how multiple rescue.
  BBSRC EASTBIO PhD Programme: Uncovering molecular details of regulation of the mRNA capping enzymes in gene expression
  Dr A Pisliakov, Prof V Cowling
Application Deadline: 5 January 2020

Funding Type

PhD Type

This 4 year PhD project is part of a competition funded by EASTBIO BBSRC Doctoral Training Partnership http://www.eastscotbiodtp.ac.uk/how-apply-0.
  The impact of mixed radiation and chemicals exposure on neuronal cytotoxicity, ageing and transcription
  Dr R Anderson
Application Deadline: 6 January 2020

Funding Type

PhD Type

A 3-year funded PhD studentship is available in the College of Health and Life Sciences at Brunel University London. Project description.
  Structure, dynamics and interactions of bacterial RNA polymerase subunits and sigma factors
  Prof L Zidek
Application Deadline: 17 December 2019

Funding Type

PhD Type

Bacterial RNA polymerase (RNAP) is a key enzyme involved in gene expression and proved target of antibiotics. Although model RNAP of Gram-negative bacteria is well characterized, RNAP of other bacterial species differs substantially in subunit composition and regulation.
  The role of phase separation in RNA polymerase II transition from initiation to elongation
  Dr F Robert
Applications accepted all year round

Funding Type

PhD Type

High resolution mapping of elongating RNA polymerase II (RNAPII) in yeast using Native Elongating Transcript sequencing (NET-seq) revealed frequent pausing events in the 5’end of genes (Churchman and Weissman, 2011).
  Functional mirror-image ribo-regulation tools
  Dr N Dixon
Application Deadline: 12 January 2020

Funding Type

PhD Type

Dual award PhD in Synthetic and Systems Biology - Manchester and Tsinghua University.
  Using synthetic biology to understand the evolution of antibiotic resistance
  Dr M Lagator, Dr C Knight
Applications accepted all year round

Funding Type

PhD Type

Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it.
  EASTBIO Defining the structural basis of Tdp1-dependent DNA repair
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr J Richardson, Dr H Interthal
Application Deadline: 5 January 2020

Funding Type

PhD Type

DNA topoisomerases are described as “magicians of the DNA world”. They allow DNA strands and double helices to “pass through each other” thereby resolving topological strain created during DNA replication and transcription.
  MRC DiMeN Doctoral Training Partnership: From Live Cells to Single-molecules: Unravelling the interplay between 3D genomic structure and gene expression
  Dr C Toseland, Dr T Craggs
Application Deadline: 6 January 2020

Funding Type

PhD Type

This studentship is focused on applying state-of-the-art single molecule imaging techniques to study the molecular basis of DNA condensation and its impact upon gene expression.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  MRC DiMeN Doctoral Training Partnership: From Live Cells to Single-molecules: Unravelling the interplay between 3D genomic structure and gene expression
  Dr C Toseland, Dr T Craggs
Application Deadline: 6 January 2020

Funding Type

PhD Type

This studentship is focused on applying state-of-the-art single molecule imaging techniques to study the molecular basis of DNA condensation and its impact upon gene expression.
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