University of Sheffield Featured PhD Programmes
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Biophysics (animal disease) PhD Projects, Programs & Scholarships

We have 16 Biophysics (animal disease) PhD Projects, Programs & Scholarships

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  Precision Medicine DTP - 3D Modeling of Changes in Genome Architecture in Development and Disease
  Research Group: Institute of Cell Biology
  Prof E Schirmer, Dr D Marenduzzo
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Defects in spatial genome organisation have recently been linked to human disease and the National Institutes of Health, USA director speculated that most as yet unidentified disease alleles will occur in non-coding genome regions.
  Development and validation of novel MRI methods using preclinical models of disease.
  Research Group: Institute of Neuroscience and Psychology
  Dr W Holmes
Applications accepted all year round

Funding Type

PhD Type

Project Description. At Glasgow’s Experimental MRI Centre we are interested in pushing the boundaries of Magnetic Resonance Imaging (MRI) and its application to biomedical research.
  Protein Misfolding and the Molecular Basis of Alzheimer’s Disease
  Dr J Viles
Applications accepted all year round

Funding Type

PhD Type

Background. World-wide one in three people over the age of 65 will die with Alzheimer’s Disease (AD). The disease is characterised by deposits of amyloid plaques and fibrils of amyloid-beta peptide (Ab) are their main constituent.
  Use of electroencephalography for the discovery of a functional marker of MCI converting to dementia. The AlzSM project.
  Dr F Tamagnini, Prof G J Stephens, Dr G Stothart
Applications accepted all year round

Funding Type

PhD Type

Dementia is the main chronic disease leading to disability amongst the elder population worldwide and it currently represents a healthcare emergency at a global level.
  (BBSRC DTP) Selective knockdown of proinflammatory microRNAs to tackle neurodegeneration and cognitive decline: myth or reality?
  Dr E Bichenkova, Prof J Neill, Dr F Roncaroli, Prof D Clarke
Application Deadline: 31 January 2020

Funding Type

PhD Type

Neurodegenerative diseases (e.g. multiple and amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases) have tremendous psychological, clinical and social impact, which becomes increasingly challenging in the global trend of population aging.
  Biomedical research in a simple non-animal model
  Prof R S B Williams
Applications accepted all year round

Funding Type

PhD Type

Research in biomedical neuroscience generally employs mammalian tissue culture experiments to look at disease-related neuronal cell function.
  Mucosal Vaccines - using Bacillus subtilis spores to develop vaccines and adjuvants against disease
  Prof S Cutting
Applications accepted all year round

Funding Type

PhD Type

Heat stable bacterial spores are being used as novel mucosal vaccines. Spores of Bacillus subtilis have been used successfully as both vaccines and adjuvants against a number of diseases.
  Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development
  Dr V Hernandez
Applications accepted all year round

Funding Type

PhD Type

Bardet-Biedl syndrome (BBS) is a debilitating, often life-limiting heritable multisystem disorder caused by dysfunction of non-motile cilia (ciliopathy).
  Understanding the negative sense RNA intermediate in picornavirus replication
  Research Group: BBSRC White Rose DTP
  Prof N J Stonehouse, Prof D.J. Rowlands
Application Deadline: 6 January 2020

Funding Type

PhD Type

Picornaviruses are responsible for a number of serious diseases, including polio and foot-and–mouth disease. There is an urgent need to develop new strategies to address the continuing issue of picornavirus infection.
  MRC DTP 4 Year PhD Programme: Molecular simulation study of the Nrf2-Keap1 pathway, the master regulator of cellular redox homeostasis
  Dr A Pisliakov, Prof A Dinkova-Kostova
Application Deadline: 11 January 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  MRC DiMeN Doctoral Training Partnership: Development and application of fast Magnetic Resonance Spectroscopic Imaging methods for neuro-chemical profiling
  Prof J Schneider, Prof S Short
Application Deadline: 6 January 2020

Funding Type

PhD Type

While Magnetic Resonance Imaging is well established to assess anatomy, structure and function in patients and in animal models of human disease alike, (routine) MR Spectroscopy tools to investigate metabolic alterations are far less common.
  Structure-function relationships governing polyphenol bioactivity with respect to plasma membranes
  Prof R A Frazier, Dr R Green
Applications accepted all year round

Funding Type

PhD Type

This project aims to investigate polyphenol binding to lipid membrane surfaces with a view to understanding how polyphenol structure and aggregation within the gastrointestinal tract (GIT) affects the bioavailability of these nutraceuticals.
  BBSRC White Rose DTP Industrial-CASE Studentship - INFUCE - Fungal β-glucan cell wall biosynthesis
  Dr C Voigt, Prof J K Hobbs
Application Deadline: 6 January 2020

Funding Type

PhD Type

A four-year BBSRC funded Industrial-CASE PhD studentship funded via the White Rose Mechanistic Biology DTP is available for entry in October 2020 in an exciting collaboration between researchers at the University of Sheffield and Syngenta, Jealotts Hill International Research Centre.
  EASTBIO Dissecting the role of the immune system in tumour initiation using experimental & computational analysis
  Dr Y Feng, Dr L Schumacher
Application Deadline: 5 January 2020

Funding Type

PhD Type

The mechanisms that modulate the pre-neoplastic stage of tumourigenesis in vivo are largely unknown due to the lack of suitable animal models.
  A molecular analysis of centrioles, centrosomes and cilia
  Prof J Raff
Application Deadline: 10 January 2020

Funding Type

PhD Type

Centrioles are barrel-shaped structures that organise the assembly of two crucial cell organelles. centrosomes and cilia.
  Molecular mechanisms of influenza virus replication
  Prof E Fodor
Application Deadline: 10 January 2020

Funding Type

PhD Type

Influenza viruses are important human and animal pathogens; they cause widespread clinical and veterinary disease and have a considerable economic impact.
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