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Biophysics (structural biology) PhD Projects, Programs & Scholarships

We have 103 Biophysics (structural biology) PhD Projects, Programs & Scholarships

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  Wellcome Trust Graduate programme in Cellular Structural Biology

Funding Type

PhD Type

The University of Oxford and Diamond Light Source, in conjunction with the Wellcome Trust, offers a four-year graduate programme in Cellular Structural Biology, leading to the PhD degree.
  EASTBIO - Putting a spin on structural biology – biomedical applications of pulsed high field electron paramagnetic resonance
  Dr B E Bode, Dr G Smith
Application Deadline: 5 January 2020

Funding Type

PhD Type

Structural biology is investigating ever more complex systems. It emerges that often capturing the essential biological context is crucial for in vitro studies to become relevant to structure and function in vivo.
  (BBSRC DTP) Electron Paramagnetic Resonance Pulsed Dipolar Spectroscopy for Structural Biology
  Dr A Bowen, Dr S Hay, Dr M Shanmugam
Application Deadline: 31 January 2020

Funding Type

PhD Type

Electron Paramagnetic Resonance is a rapidly expanding suit of techniques used for the study of complex (bio)molecules that possess spin-active moieties with unaired electrons.
  Structural and functional studies on ciliary proteins required for vision
  Research Group: BBSRC White Rose DTP
  Prof C A Johnson, Dr J.J.B. Cockburn, Dr R.F. Thompson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Rod and cone photoreceptor cells in the retina detect light, allowing us to see. When specialised cellular structures in photoreceptors are disrupted, this is a major cause of childhood and adult-onset blindness.
  Cryo-EM structural analysis of amyloid fibrils
  Prof M Fändrich, Dr M Schmidt
Applications accepted all year round

Funding Type

PhD Type

The Institute of Protein Biochemistry at Ulm University, Germany, investigates the molecular basis of amyloid diseases, such as Alzheimer’s disease and systemic amyloidosis.
  Understanding the mechanism of RNA recognition by La-related proteins
  Prof MR Conte
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Prof. Sasi (Maria R) Conte (https://www.kcl.ac.uk/people/sasi-conte), in the Randall Centre for Cell and Molecular Biophysics, King’s College London (https://www.kcl.ac.uk/lsm/research/divisions/randall).
  Structural and biophysical characterisation of novel plastic degrading enzymes
  Dr M Zahn, Prof J McGeehan, Dr A Pickford
Application Deadline: 7 February 2020

Funding Type

PhD Type

Applications are invited for a fully-funded four year PhD studentship to commence in October 2020. The PhD will be based at the University’s Centre for Enzyme Innovation (CEI), and will be supervised by Dr Michael Zahn, Prof John McGeehan and Dr Andy Pickford.
  Targeting an Achilles heel in bacterial outer membrane biogenesis: Strategies to combat bacterial infection by targeting the periplasmic chaperone SurA
  Research Group: BBSRC White Rose DTP
  Dr A Zhuravleva, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

In February 2017 the World Health Organisation published a list of antibiotic-resistant "priority pathogens" – a catalogue of 12 families of bacteria that pose the greatest threat to human health.
  Ion channel clustering in neuronal membranes
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions.
  EASTBIO Using cryo-EM to investigate chromatin structure in Trypanosoma brucei
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr M Wilson
Application Deadline: 5 January 2020

Funding Type

PhD Type

Second Supervisor. David Horn, University of Dundee. We are interested in understanding how the basic unit of chromatin, the nucleosome, compacts and controls access to DNA.
  The mechanism of gating and transport of pentameric Magnesium ion channels
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Magnesium ions are a co-factor in many important biological processes particularly because of the requirement for Mg2+ in the hydrolysis of Adenosine tri-phosphate, the ubiquitous cellular energy source.
  Development of Novel Crystallization Methods for Integral Membrane Proteins
  Dr G Patchornik
Applications accepted all year round

Funding Type

PhD Type

Our research is focused on one of the major barriers in Structural biology. growing high quality three dimensional (3D) crystals of integral membrane proteins for structural analysis.
  PhD Position in Cryo Electron Microscopy of Rhodopsin Cyclases
  Prof P Wendler
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic rhodopsin guanylyl cyclases (RhGC) and rhodopsin phosphodiesterases (RhPDE) combine a rhodopsin photoreceptor module with an enzymatic unit that catalyzes the conversion of cyclic nucleotides to the corresponding 5’-phosphate nucleotide or vice versa.
  (BBSRC DTP CASE) Design of a light-driven biocatalyst
  Prof D Leys, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

Illumination is able to unlock a wide range of photochemical reactions, but light is rarely used by living organisms. In fact, to date only three light dependent enzymes have been described in detail.
  (BBSRC DTP) Reductive dehalogenation and detoxification of pollutants
  Prof D Leys, Dr S Hay, Prof A Munro
Application Deadline: 31 January 2020

Funding Type

PhD Type

Many of the key pollutants released into the environment are halogenated organic molecules, containing at least one or more chloride or bromide atoms.
  China Scholarship Council - Structural and membrane biology of polarized trafficking
  Dr D H Murray, Dr J Januschke
Application Deadline: 15 January 2020

Funding Type

PhD Type

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students.
  EASTBIO Defining the structural basis of Tdp1-dependent DNA repair
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr J Richardson, Dr H Interthal
Application Deadline: 5 January 2020

Funding Type

PhD Type

DNA topoisomerases are described as “magicians of the DNA world”. They allow DNA strands and double helices to “pass through each other” thereby resolving topological strain created during DNA replication and transcription.
  Fostering development of ‘smart’, responsive therapeutics against cancer-related microRNAs.
  Dr E Bichenkova, Prof D Clarke, Dr H Aojula
Applications accepted all year round

Funding Type

PhD Type

Short functional non-coding microRNAs are implicated in many types of cancer, and thus can be used as biological targets for development of more selective and powerful anticancer therapies.
  Department of Biochemistry: 3- and 4-year PhD/DPhil Studentships

Funding Type

PhD Type

The Department of Biochemistry conducts interdisciplinary research applying cutting-edge techniques in bionanotechnology, biophysics, computational biology…
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  Investigating the binding of MeCP2 on chromatin
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr M Wilson, Prof A P Bird
Application Deadline: 5 January 2020

Funding Type

PhD Type

MeCP2 is a nuclear protein that binds to methylated DNA in the genome. It is highly abundant in neurons and mutations in the MECP2 gene cause the severe X-linked autism spectrum disorder Rett syndrome.
  Designing and evolving plastic-degrading enzymes for new function
  Dr B Lichtenstein, Prof J McGeehan, Dr S Robson
Application Deadline: 7 February 2020

Funding Type

PhD Type

Applications are invited for a fully-funded four year PhD studentship to commence in October 2020. The PhD will be based at the University’s Centre for Enzyme Innovation (CEI), and will be supervised by Dr Bruce Lichtenstein, Prof.
  Detection in cells of protein interactions on pre-mRNA during the regulation of splicing
  Prof I C Eperon, Dr S Cowley
Application Deadline: 12 January 2020

Funding Type

PhD Type

One of the biggest challenges in molecular biology is presented by the selection of sites for RNA splicing. We cannot overstate its importance or apparent complexity.
  IMPRS "From Molecules To Organisms”: Next application opens January 2020

Funding Type

PhD Type

Our PhD program in the life sciences places special emphasis on interdisciplinary interactions. We want to train the next generation of scientists to study complex biological processes that cannot be adequately understood within the limits of a single discipline.
  EMBL Australia Partnership PhD Program

Funding Type

PhD Type

Undertake interdisciplinary, postgraduate research for a PhD degree at Australia's top life science laboratories. Successful students will receive generous scholarships and travel grants while undertaking their PhD at an EMBL Australia laboratory in Melbourne, Sydney, Canberra or Adelaide.
  The chemistry and biophysics of phosphoryl transfer enzymes
  Prof J Waltho, Dr A Almond
Applications accepted all year round

Funding Type

PhD Type

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates.
  Combining Synthetic Biology and Modelling to Understand and Predict Evolution
  Dr M Lagator, Dr J-M Schwartz
Applications accepted all year round

Funding Type

PhD Type

Mutations, and their effects on organismal fitness, lie at the heart of understanding and predicting evolution. Because of its central role in determining evolutionary outcomes, much experimental and theoretical effort has been put into describing the fitness effects of mutations.
  Eastbio PhD Programme: Targeting the MYCBP2 E3 ubiquitin ligase with small molecules
  Prof A Ciulli, Dr S Virdee
Application Deadline: 5 January 2020

Funding Type

PhD Type

This 4 year PhD project is part of a competition funded by EASTBIO BBSRC Doctoral Training Partnership http://www.eastscotbiodtp.ac.uk/how-apply-0.
  MSc by Research Programme: Bringing proteins together with small molecules
  Prof A Ciulli
Application Deadline: 16 July 2020

Funding Type

PhD Type

This course allows you to work alongside our world renowned experts from the School of Life Sciences and gain a ’real research’ experience.
  Investigating metalloprotein mechanism using ‘physiological’ X-ray absorption spectroscopy
  Dr P Ash
Application Deadline: 4 February 2020

Funding Type

PhD Type

A wide variety of metalloproteins, utilising a range of earth-abundant metals, are vital to many biological processes. Changes in metal-based oxidation state are critical to the function of metalloproteins with diverse roles in electron transfer and redox catalysis.
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