Norwich Research Park Featured PhD Programmes
Aberdeen University Featured PhD Programmes
Norwich Research Park Featured PhD Programmes

Biophysics PhD Projects, Programs & Scholarships

We have 305 Biophysics PhD Projects, Programs & Scholarships

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We have 305 Biophysics PhD Projects, Programs & Scholarships

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Characterisation of DNA-protein crosslink proteolysis repair in cancer therapy with the focus on trapped-PARP1 toxicity

DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA. DPCs are induced by endogenous aldehydes, chemotherapeutic drugs (such as PARP1 inhibitors) and ionising radiation in hypoxic cells. Read more

Cascading failure of the aorta - The role of collagen degradation in the development of aortic dissection

The aorta is the largest conduit for blood flow in the human body and vital for cardiovascular health. Aortic dissection (AD) occurs when there is a split in the wall of the aorta, resulting in the creation of an artificial channel for blood flow, which can lead to rupture. Read more

Nanomechanical alterations in Acute Type A Aortic Dissections

Acute Type A aortic dissection (AAD), involves a splitting of the tunica media in the aortic wall. AAD is life-threatening and often occurs in young patients with no prior relevant medical history. Read more

Predicting patient specific properties of the dissection flap in aortic emergencies

The aorta is the main blood vessel channelling blood from the heart to all organs of the body. Under certain circumstances the aorta can split longitudinally resulting in a double-barrelled aorta, called an aortic dissection. Read more

Understanding complement system dysregulation in the tumour microenvironment

Inducing a stress response analogous to anti-viral immunity is important for maximising immune responses against the tumour. However, tumours evolve evasion strategies that can limit these responses. Read more

Understanding the effects of immunomodulatory therapies on radiation response

Radiotherapy can ablate tumours through inducing both DNA damage and anti-tumour inflammatory responses. However, innate immunity pathways mounting inflammatory responses can also afford cell intrinsic radioresistance. Read more

The crosstalk between tumour microenvironments and MAFF to determine transcriptional activation or repression

Radiation is effective in treating many types of cancers by inducing oxidative stress through the generation of reactive oxygen species (ROS) that result in DNA damage, in particular, DNA double strand breaks (DSBs). Read more

The sex and geometry of the gastrointestinal tract in health and disease

  Research Group: Gut Signalling & Metabolism
The gastrointestinal (GI) tract controls appetite and metabolism through its crosstalk with other organs. GI disorders such as inflammatory bowel disease (IBD) can be life-long conditions and affect people of all ages. Read more

Targeting polymerase theta as a way to improve radiotherapy and immunotherapy.

Despite technical improvements in radiation delivery, survival rates following radical radiotherapy remain poor for many tumour types and the radiation delivered to adjacent tissues is still frequently associated with significant side-effects. Read more

Ubiquitin signalling in the pathogenesis and radiotherapy of glioblastoma

Glioblastoma accounts for more than 4000 deaths every year in the UK. The cornerstone of glioblastoma treatment is constituted by maximal surgical resection, radiotherapy and chemotherapy. Read more

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