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The University of Manchester, Faculty of Biology, Medicine and Health Biophysics PhD Projects, Programs & Scholarships

We have 15 The University of Manchester, Faculty of Biology, Medicine and Health Biophysics PhD Projects, Programs & Scholarships

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  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Combining Synthetic Biology and Modelling to Understand and Predict Evolution
  Dr M Lagator, Dr J-M Schwartz
Applications accepted all year round

Funding Type

PhD Type

Mutations, and their effects on organismal fitness, lie at the heart of understanding and predicting evolution. Because of its central role in determining evolutionary outcomes, much experimental and theoretical effort has been put into describing the fitness effects of mutations.
  Computer-aided molecular design: improved ligand docking using electronic structure and molecular dynamics simulations
  Dr R A Bryce, Dr N Burton
Applications accepted all year round

Funding Type

PhD Type

In structure-based drug design, computational modelling techniques are frequently used to predict the orientation and affinity with which a ligand binds to its protein receptor.
  Deciphering the neural code of the hippocampus
  Dr M Montemurro, Dr J Gigg
Applications accepted all year round

Funding Type

PhD Type

Background. The brain processes and stores information about our lives and the world that surrounds us. At the neural scale, information is encoded through the precise timing of activity across populations of neurons.
  Fostering development of ‘smart’, responsive therapeutics against cancer-related microRNAs.
  Dr E Bichenkova, Prof D Clarke, Dr H Aojula
Applications accepted all year round

Funding Type

PhD Type

Short functional non-coding microRNAs are implicated in many types of cancer, and thus can be used as biological targets for development of more selective and powerful anticancer therapies.
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  Ion channel clustering in neuronal membranes
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  Proteomic approach to understand mitochondrial quality control under normal and stress conditions
  Dr H Lu, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Defects in protein quality control lead to the accumulation of misfolded and damaged proteins, which play an important role in many diseases (e.g.
  The mechanism of gating and transport of pentameric Magnesium ion channels
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Magnesium ions are a co-factor in many important biological processes particularly because of the requirement for Mg2+ in the hydrolysis of Adenosine tri-phosphate, the ubiquitous cellular energy source.
  The nanoscale organisation of immune cell surfaces in health and disease
  Prof D Davis
Applications accepted all year round

Funding Type

PhD Type

Super-resolution microscopes, celebrated in the 2014 Nobel Prize for Chemistry, are one of the tools that allow us to study immune cells in unprecedented detail.
  The role and regulation of microtubules during axon growth and degeneration
  Prof A Prokop
Applications accepted all year round

Funding Type

PhD Type

Axons are the enormously long cable-like processes of neurons that wire the nervous system. These delicate structures have to be maintained for a life time.
  The role of cell adhesion proteins in healthy and cancerous epithelial cells
  Dr C Ballestrem, Prof D R Garrod
Applications accepted all year round

Funding Type

PhD Type

The cells’ ability to properly communicate with its environment is fundamental for the healthy development of individual organisms.
  Understanding and minimizing radiation damage in breast tissues
  Dr M Sherratt, Miss C Kirwan, Prof S Cartmell
Applications accepted all year round

Funding Type

PhD Type

Human beings are subjected to many forms of radiation both natural (principally ultraviolet radiation [UVR]) and artificial (diagnostic and therapeutic X-rays).
  Using synthetic biology to understand the evolution of antibiotic resistance
  Dr M Lagator, Dr C Knight
Applications accepted all year round

Funding Type

PhD Type

Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it.
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