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Brunel University London, Biosciences PhD Projects, Programs & Scholarships

We have 15 Brunel University London, Biosciences PhD Projects, Programs & Scholarships

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  Budding yeast as a model for sudden cardiac death
  Dr T Hoefken
Applications accepted all year round

Funding Type

PhD Type

Sudden unexpected cardiac death is responsible for about half of all heart disease deaths. It is an unexpected death caused by a change in heart rhythm.
  Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development
  Dr V Hernandez
Applications accepted all year round

Funding Type

PhD Type

Bardet-Biedl syndrome (BBS) is a debilitating, often life-limiting heritable multisystem disorder caused by dysfunction of non-motile cilia (ciliopathy).
  Developing new antibody-based therapeutics for neuroblastoma
  Prof A Sala
Applications accepted all year round

Funding Type

PhD Type

Metastatic neuroblastoma is a cancer of the nervous system that kills the majority of the affected children. Although there have been tremendous advances in the understanding of the molecular causes of the disease, patients are still treated with highly toxic mixtures of chemicals and radiation.
  Disrupting biofilm formation in nosocomial pathogens
  Dr R McCarthy
Applications accepted all year round

Funding Type

PhD Type

A biofilm by definition is a structured community of bacterial cells enclosed in a self-produced polysaccharide matrix and adherent to an inert or living surface.
  Disrupting the regulatory mechanisms that allow hospital acquired infections to resist antibiotic therapy.
  Dr R McCarthy
Applications accepted all year round

Funding Type

PhD Type

The discovery of penicillin over 90 years ago and its subsequent uptake by healthcare systems around the world revolutionised global health and wellbeing.
  Egr2 and 3 mediated T cell tolerance in cancer and their impact in immune checkpoint therapy
  Dr S Li
Applications accepted all year round

Funding Type

PhD Type

Tumour infiltrated lymphocytes (TILs) contain tumour reactive T cells and have been used as adoptive cell transfer therapy in patients which can mediate cancer regression.
  Genetic and non-genetic factors involved in risk of cardiovascular diseases
  Dr R Pazoki
Applications accepted all year round

Funding Type

PhD Type

Main Aim. To identify genetic and non-genetic causes of cardiovascular diseases. Cardiovascular diseases including hypertension, myocardial infarction, heart failure, and stroke are the leading causes of mortality worldwide and are expected to keep rising.
  Investigating Therapeutic Effect of Different Antioxidants in Friedreich’s Ataxia (FRDA)
  Dr S Anjomani-Virmouni
Applications accepted all year round

Funding Type

PhD Type

Friedreich’s ataxia (FRDA) is an inherited neurodegenerative disorder caused by epigenetic silencing of the frataxin gene. It is the most common inherited ataxia, affecting 1:50,000 Caucasians, and is characterised by neurodegeneration, cardiomyopathy, diabetes mellitus and skeletal deformities.
  Involvement of the matrix protein SPARC in the dynamic interaction between tumour and host cells
  Dr G Stenbeck, Dr E Karteris
Applications accepted all year round

Funding Type

PhD Type

Tumour growth depends on the crosstalk between malignant and surrounding stromal cells (fibroblasts, osteoblasts, endothelial cells and inflammatory cells).
  Marine Mammal Ecotoxicology
  Dr G Troisi
Applications accepted all year round

Funding Type

PhD Type

Exposure to persistent organic pollutants such has been shown to cause reproductive failure in wild seals and other aquatic mammal species and endocrine disruptive toxic mechanisms are believed to be involved.
  Mechanisms of cilia biogenesis and signalling
  Dr B Tanos
Applications accepted all year round

Funding Type

PhD Type

Cilia are sensory organelles that detect mechanical and chemical stimuli from the environment. They arise from centrioles and function as “antennae” that receive and integrate extracellular signals.
  Nanoparticles in drug delivery
  Dr G Stenbeck, Dr U Kishore
Applications accepted all year round

Funding Type

PhD Type

Nanoparticles (NPs) are materials with overall dimensions in the nano scale range (5nm-100nm). Due to their unique physicochemical properties, they have found a wide range of applications and are currently explored as drug and gene delivery vehicles.
  Role of cilia in oncogenic signaling and drug resistance
  Dr B Tanos
Applications accepted all year round

Funding Type

PhD Type

Primary cilia are microtubule-based antennae that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer remains unclear.
  Seeking critical branch points in bacterial evolution with comparative genomics
  Prof N Saunders, Mr A Khan
Applications accepted all year round

Funding Type

PhD Type

This is a bioinformatics and comparative genomics-focussed project, seeking to identify the basis of speciation and sub-speciation of bacterial species accounting for the development of individual and independent lineages.
  Telomere length elongation following treatment with chemotherapeutic drugs. Aim: To investigate the mechanisms which leads to telomere length elongation after treatment with tricostatin A and azacytidine.
  Dr T Roberts
Applications accepted all year round

Funding Type

PhD Type

Telomeres are specialised structures, which are present at the ends of chromosomes and serve to protect the chromosome from degradation during cell division.
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