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We have 10 Bioinformatics (infection model) PhD Projects, Programmes & Scholarships

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Bioinformatics (infection model) PhD Projects, Programmes & Scholarships

We have 10 Bioinformatics (infection model) PhD Projects, Programmes & Scholarships

CRISPR/Cas9 probing of virulence factors in dermatophytes

One of the most widespread fungal infections affecting 20-25% of the global population is dermatophytosis. This is caused by fungi that infect the skin, nails, and hair, leading to common conditions such as athlete’s foot or ringworm. Read more

Competition and cooperation relationships within human microbial communities.

Typical studies of the human microbiome identify dysbiosis by sampling from healthy individuals, comparing them to individuals with a particular disease state, and reporting changes in the presence and/or abundance of bacterial species. Read more

Exploring Viral Nucleic Acid Machinery via Cryo Electron Microscopy to Advance Biomedicine

Viruses, these tiny but potent life forms, are all around us, infecting various organisms and directly affecting human health. Although in most cases, viral infection is not life threatening, in the minority of cases it leads to long-term disorders including cancer. Read more

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more

Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more

Modelling the respiratory microbiome in chronic lung disease and healthy ageing

The Respiratory Microbiome Group seeks to understand the interactions between complex communities of bacteria, fungi and viruses with the human respiratory tract in both disease (acute infections and chronic lung disease) and in health or healthy ageing. Read more

Systemic infections accelerate tau spreading by promoting glial activation

Alzheimer’s disease (AD) is a neurodegenerative disease, with a complex biology. In this PhD project, we aim to explore the cellular and molecular mechanisms underlying tau pathology. Read more
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