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Biotechnology (structural) PhD Projects, Programs & Scholarships

We have 34 Biotechnology (structural) PhD Projects, Programs & Scholarships

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We have 34 Biotechnology (structural) PhD Projects, Programs & Scholarships

Using cryoEM to understand pathogen antibiotic transport and resistance

Background. A number of dangerous pathogens are increasingly resistant to our front-line antibiotics, raising the prospect of a ‘post-antibiotic era’ where we can no longer treat infectious diseases. Read more

The mechanism of regulation of protein synthesis via eIF2 molecular complexes

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more

Protein engineering enzymes for Industry

 . We are interested in key features of the protein sequence - structure - function relationship, and how this information can be translated to health. Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Simulation-led investigation and engineering of enzymes involved in abyssomicin antibiotic biosynthesis

Enzymes are remarkable biocatalysts that allow rapid, selective and efficient catalysis under mild conditions. Biotechnology exploits the outstanding rate-enhancing properties of these natural biocatalysts to manufacture high added-value products. Read more

Pushing the Speed Limits of High-Speed Atomic Force Microscopy

  Research Group: School of Physics and Astronomy
Understanding the structural dynamics of complex molecules is vital to advancing our knowledge of materials, medicine and diseases, yet there are few techniques which can capture motions at high enough speeds or resolution to understand the underlying behaviour. Read more

The chemistry and biophysics of phosphoryl transfer enzymes

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates. Read more

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