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Biotechnology (transgenic) PhD Projects, Programs & Scholarships

We have 4 Biotechnology (transgenic) PhD Projects, Programs & Scholarships

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  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  Understanding how altered GABA signalling in the brain’s master clock contributes to circadian rhythm disruption in Alzheimer’s disease. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr M Belle
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Mino Belle, Institute of Biomedical and Clinical Science, Medical School, University of Exeter. Dr James Hodge, Faculty of Life Sciences, University of Bristol.
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