Bioinformatics (vivo) PhD Projects, Programmes & Scholarships

We have 30 Bioinformatics (vivo) PhD Projects, Programmes & Scholarships

Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

Supervisors: Dr G Mavria, Dr S Bell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Molecular mechanisms underlying the anti-atherogenic actions of natural products

Cardiff University Cardiff School of Biosciences

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for most deaths in the western world with mortality increasing at a marked rate in developing. Read more

Supervisors: Dr D Ramji, Dr T Hughes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health

Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more

Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Inhibiting cell metabolism to enhance tumour cell death

University of Leeds Faculty of Medicine and Health

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Supervisors: Dr S Papa, Dr R Tooze

Year round applications PhD Research Project Self-Funded PhD Students Only

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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Determination of the non-coding RNAs in the knee joint tissues of dogs at differing risk to cranial cruciate ligament rupture.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Background. The cranial cruciate ligment (CCL) is the most frequently damaged ligament of the canine knee joint following injuries and age-related ligament breakdown, leading to the development of osteoarthritis (OA). Read more

Supervisors: Prof E Comerford, Prof M Peffers

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Repurposing drugs as new treatments for breast cancer

University of Leeds Faculty of Medicine and Health

Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more

Supervisors: Dr L Matthews, Dr P Meakin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Repeat Physical Traumas an initiator for motor neuron disease (MND): an insight from professional rugby

University of Liverpool Institute of Life Course and Medical Sciences

Motor Neuron Disease (MND) is a devastating condition affecting neuronal cells responsible for voluntary muscle movement. The risk of developing MND is 1 in 300, predominantly in individuals over 50. Read more

Supervisors: Dr C Staunton, Prof A McArdle

20 June 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Systemic infections accelerate tau spreading by promoting glial activation

University of Southampton School of Biological Sciences

Alzheimer’s disease (AD) is a neurodegenerative disease, with a complex biology. In this PhD project, we aim to explore the cellular and molecular mechanisms underlying tau pathology. Read more

Supervisor: Prof J Teeling

17 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Manipulation of neuroimmune responses and behaviour by infectious agents

University of Leeds Faculty of Biological Sciences

This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more

Supervisors: Dr G Mcconkey, Dr S Clapcote

Year round applications PhD Research Project Self-Funded PhD Students Only

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