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Biotechnology PhD Projects, Programs & Scholarships

We have 298 Biotechnology PhD Projects, Programs & Scholarships

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We have 298 Biotechnology PhD Projects, Programs & Scholarships

Genomics of inbreeding in Seychelles warblers

In just 50 years the global Seychelles warbler population has recovered from <30 birds on a single island, Cousin, to a population of several thousand on multiple islands thanks to a combination of habitat restoration and translocation. Read more

PhD Project - Messenger: mRNA-based therapies with Enhanced Site Selective Expression using Cold Plasma and Ultrasound

Overview. mRNA presents several advantages over traditional viral vector and DNA-based approaches including relatively simple scaling of manufacturing, potent but short lasting and relatively non-immunogenic protein expression, and limited capacity for host cell genome integration events occurring. Read more

Understanding the gene regulatory landscape of embryonic stem cells and cancer cells

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more

Combining Synthetic Biology and Modelling to Understand and Predict Evolution

Mutations, and their effects on organismal fitness, lie at the heart of understanding and predicting evolution. Because of its central role in determining evolutionary outcomes, much experimental and theoretical effort has been put into describing the fitness effects of mutations. Read more

The mechanism of regulation of protein synthesis via eIF2 molecular complexes

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more

Uncovering the molecular mechanisms underlying spinal cord regeneration

About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have very poor capacities to regenerate, thus resulting in a permanent loss of function. Read more

Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene. Read more

Evolution of vertebrate blood vessels

The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks. Read more

Understanding disease mechanisms in autoimmune inflammatory muscle disease

The idiopathic inflammatory myopathies are a spectrum of rare autoimmune disorders characterized by inflammation of muscle tissue (myositis), which leads to muscle weakness and fatigue, and heterogeneous systemic organ involvement. Read more

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