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University of Sheffield, Department of Molecular Biology and Biotechnology Biotechnology PhD Projects, Programs & Scholarships

We have 14 University of Sheffield, Department of Molecular Biology and Biotechnology Biotechnology PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 14
  Bactofilins and the bacterial cytoskeleton
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Newly developed light and electron microscopy methods are revolutionising our understanding of bacterial cells. Once thought to be simple, bacteria have now been recognised at highly organised cells using many elements previously only known from eukaryotes.
  Biogenesis of the Clostridium difficile cell surface
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Clostridium difficile infection (CDI) is a major cause of morbidity and mortality in our hospitals. Infection normally follows disruption of the gut normal flora by broad-spectrum antibiotic treatment.
  Development of a novel immunotoxin
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

Immunotoxins represent a form of immunotherapy whereby antibodies are used to target a toxin, usually to cancer or infected host cells.
  Development of Intronless Expression Plasmids for Biomanufacturing of Therapeutic Proteins
  Prof S A Wilson, Dr E Thomson, Dr I Sudbery
Application Deadline: 10 January 2020

Funding Type

PhD Type

Therapeutic proteins such as antibodies are a successful class of biologic drug used to treat a wide range of diseases in areas such as oncology, respiratory, inflammation, autoimmunity and cardiology.
  Functional analysis of novel genes important in the physiology and pathogenesis of the human pathogen Campylobacter jejuni
  Prof D J Kelly
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni and E. coli are the commonest cause of human bacterial gastroenteritis worldwide. Although pathogenic in humans, C.
  Gliding motility in bacteria
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Motility is important for bacterial survival and facilitates colonisation and dispersal of bacteria. While swimming and type IV pili-based swarming is relatively well understood, gliding or adventurous motility, a form of surface-associated motility is still enigmatic.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  Investigating Photosynthesis in Nannochloropsis – An Important Algal Genus for Biofuel Production
  Dr D J Gilmour
Applications accepted all year round

Funding Type

PhD Type

One of the key insights from phylogenetic studies of eukaryotic microorganisms is the enormous diversity within the microalgal group with green algae being similar to plants and other groups such as diatoms being very different.
  Investigating Photosynthesis in Nannochloropsis – An Important Algal Genus for Biofuel Production
  Dr D J Gilmour
Applications accepted all year round

Funding Type

PhD Type

One of the key insights from phylogenetic studies of eukaryotic microorganisms is the enormous diversity within the microalgal group with green algae being similar to plants and other groups such as diatoms being very different.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
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