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The University of Manchester, Faculty of Biology, Medicine and Health Biotechnology PhD Projects, Programs & Scholarships

We have 42 The University of Manchester, Faculty of Biology, Medicine and Health Biotechnology PhD Projects, Programs & Scholarships

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  (A*STAR) Engineering the recognition of antibodies by bacterial superantigens
  Prof J P Derrick, Dr F Hayes
Application Deadline: 31 January 2020

Funding Type

PhD Type

Superantigens are proteins which have the ability to cause hyperactivation of T cells; they are produced by certain bacteria or viruses as a defence mechanism against attack by the immune system.
  (BBSRC DTP CASE) Analysing the efficiency of protein secretion using Lattice Lightsheet Microscopy
  Prof V Allan, Prof M Lowe, Prof S Cartmell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Protein-based biopharmaceuticals are of tremendous importance both for providing disease treatments, and for the UK economy. They are typically manufactured using mammalian host cells, but some are much harder to produce than others.
  (BBSRC DTP CASE) Jellyfish-collagen hydrogels for culture and differentiation of human mesenchymal stem cells and 3D cartilage bioprinting
  Dr J Bella, Dr S Richardson, Dr M Domingos
Application Deadline: 31 January 2020

Funding Type

PhD Type

We are looking for an enthusiastic and talented graduate from a relevant biomedical or materials science degree to develop next-generation, sustainable collagen-based scaffolds for stem cell culture, differentiation, and 3D bioprinting, aimed at tissue regeneration applications.
  (BBSRC DTP) Characterising the proteolytic network of plant cathepsin B
  Dr P Gallois, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

Programmed Cell Death (PCD) is a process that is critical to all organisms for development and defence against pathogens. The process of PCD in plants does not mirror what has been described in animal apoptosis and represents a novel alternative pathway still to be fully discovered.
  (BBSRC DTP) Exploiting transcriptional regulation to improve plant cell wall as a feedstock for the sustainable production of biofuels and other chemicals
  Prof S Turner, Dr M Kim, Prof A Sharrocks
Application Deadline: 31 January 2020

Funding Type

PhD Type

Cellulose is a polymer of glucose and its remarkable structural properties means it is the world’s most abundant biopolymer. Cellulose from higher plants is an abundant source of renewable material that can be used as a source of raw material for chemical and fuel production, or for generating novel biomaterials.
  (BBSRC DTP) Improving 3D X-ray Imaging of Live Cells and Soft Tissues
  Dr M Sherratt, Prof S Cartmell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Clinical X-ray imaging in three dimensions (commonly referred to as a CT scan) is a key diagnostic tool. Micro-computed X-ray tomography (microCT) has the potential to image relatively large biological samples in 3D at sub-micron resolution.
  (BBSRC DTP) Mapping Notch endocytic signalling pathways via quantitative proteomics in Drosophila melanogaster
  Prof S Hubbard, Dr M Baron, Prof C Mills
Application Deadline: 31 January 2020

Funding Type

PhD Type

Extracellular signalling allows cells to communicate with one another in the context of tissues and influence the fate of their neighbouring cells, transducing signals from the external environment to the nucleus to affect the expression of target genes.
  (BBSRC DTP) Mapping Notch trafficking using immunofluorescence and computer vision
  Dr N Thacker, Dr M Baron, Dr P Bromiley
Application Deadline: 31 January 2020

Funding Type

PhD Type

The functional regulation of proteins in cells is strongly related to their spatial distributions. This is particularly true of signalling proteins, which may be switched on and off by transfer between different locations.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  (BBSRC DTP) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation
  Prof M Ashe, Dr M Pool, Prof C M Grant
Application Deadline: 31 January 2020

Funding Type

PhD Type

RNA granules play key roles in cells controlling many aspects of mRNA fate. For instance, in response to stress the relocalisation of mRNAs to mRNA processing bodies (P-bodies) and stress granules facilitates the degradation or storage of unwanted or valuable mRNAs, respectively.
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