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University of Leeds Biotechnology PhD Projects, Programs & Scholarships

We have 11 University of Leeds Biotechnology PhD Projects, Programs & Scholarships

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  A mechanistic understanding of allosteric regulation of neuronal sodium-activated potassium channels
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr S Muench, Dr A Kalli
Applications accepted all year round

Funding Type

PhD Type

The sodium-activated potassium channel KNa1.1 (KCNT1, Slack, Slo2.2) is found in neurons and couples sodium influx to excitability.
  Control and inhibition of virus replication
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A.K Tuplin
Applications accepted all year round

Funding Type

PhD Type


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Enhancing stability of biocatalyst for fuel cells and bioelectrocatalysis
  Prof L J C Jeuken, Dr P Beales
Applications accepted all year round

Funding Type

PhD Type

Progress in biotechnology over the last two decades has greatly increased the use of biocatalyst in the industrial production of fine chemicals.
  How protective signals from the gut modify neuronal activity and behaviour, using C. elegans as a model system.
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen
Applications accepted all year round

Funding Type

PhD Type

Amyloid protein misfolding leading to loss of neuronal function are fundamental pathogenic mechanisms of numerous age-associated neurodegenerative diseases, including Alzheimer’s (AD).
  Mathematical Virology: A New Mathematical Approach to Viral Evolution Grounded in Experiment
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Mathematical modelling of natural phenomena has the potential to be predictive but requires direct verification by experiment. Such models can then be very powerful indicators of our understanding and they permit in silico simulations of situations that are difficult to test experimentally.
  Structural characterisation of cellular mechanisms for the valorisation of water resources
  Dr Y Benitez-Alfonso, Prof A Baker, Dr R Frank
Applications accepted all year round

Funding Type

PhD Type

Phosphorus is essential to all living organisms but limited in its biological active form while at the same time representing a major contaminant in waste water.
  Synthetic Virology: Development of gene delivery vectors/synthetic vaccines
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

There is worldwide interest in exploiting our modern understanding of genomics to target gene expression therapeutically via a variety of mechanisms, such as transgene insertion and CRISPR-Cas gene editing.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  New approaches for studying and understanding Cancer
  Research Group: Molecular and Nanoscale Phsyics
  Prof SD Evans
Applications accepted all year round

Funding Type

PhD Type

One of the key questions in cancer research is what drives cells to switch from a normal healthy state to a cancerous one, in which they continually divide and reproduce.
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